Cyclization of aryl 3-aryl propynoates into 4-arylcoumarins catalyzed by cyclometalated Platinum(II) complexes

Olesia Zaitceva, Valérie Bénéteau, Dmitry S. Ryabukhin, Ivan I. Eliseev, Mikhal A. Kinzhalov, Benoit Louis, Aleksander V. Vasilyev, Patrick Pale

Research outputpeer-review

Abstract

Cyclometalated (ppy)PtII complexes (ppy = 2-phenylpyridinato-C2,N) catalyze the intramolecular cyclization of aryl propynoates to form coumarins and benzocoumarins. The complex [(ppy)PtCl(MeCN)] (5 mol %) was the most active and efficient catalyst for such reaction, especially in the presence of AgSbF6 (15 mol %) in 1,2-dichloroethane. With this catalytic system, a wide range of substituents and functional groups proved compatible with the cyclization process, leading to a large variety of substituted coumarins and benzocoumarins (22 examples, 77–99%)

Original languageEnglish
Article number131029
JournalTetrahedron
Volume76
Issue number14
Early online date12 Feb 2020
DOIs
Publication statusPublished - 3 Apr 2020

Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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