The chapter analyzes sanctions as an important tool of US foreign policy. The main attention is paid to the psychological aspect of sanctions within the US strategic psychological warfare with Russia. The author pays a lot of attention to the purposes, forms, and methods of use of the Countering America’s Adversaries Through Sanctions Act in the context of the strategic psychological warfare, as well as to some possible areas of the Russian response to that law in the sphere of strategic communication. The influence of the psychological aspect of US sanctions on the deterioration of relations between the EU and Russia is considered.