Complex syndromes of chronic pain, fatigue and cognitive impairment linked to autoimmune dysautonomia and small fiber neuropathy

Yehuda Shoenfeld, Varvara Rabkova, Carmen Scheibenbogen, Louise Brinth, Manuel Martinez-Lavin, Shuichi Ikeda, Harald Heidecke, Abdulla Watad, Nicola L. Bragazzi, Joab Chapman, Leonid P. Churilov, Howard Amital

Research output

6 Citations (Scopus)

Abstract

Chronic fatigue syndrome, postural orthostatic tachycardia syndrome, complex regional pain syndrome andsilicone implant incompatibility syndrome are a subject of debate among clinicians and researchers. Both thepathogenesis and treatment of these disorders require further study. In this paper we summarize the evidenceregarding the role of autoimmunity in these four syndromes with respect to immunogenetics, autoimmune co-morbidities, alteration in immune cell subsets, production of autoantibodies and presentation in animal models.These syndromes could be incorporated in a new concept of autoimmune neurosensory dysautonomia with thecommon denominators of autoantibodies against G-protein coupled receptors and smallfiber neuropathy.Sjogren's syndrome, which is a classical autoimmune disease, could serve as a disease model, illustrating theconcept. Development of this concept aims to identify an apparently autoimmune subgroup of the disputabledisorders, addressed in the review, which may most benefit from the immunotherapy.
Original languageEnglish
Article number108384
Number of pages11
JournalClinical Immunology
Volume214
Publication statusPublished - 18 Mar 2020

Scopus subject areas

  • Medicine(all)

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