Combined Immunization With Attenuated Live Influenza Vaccine and Chimeric Pneumococcal Recombinant Protein Improves the Outcome of Virus-Bacterial Infection in Mice

T. Kramskaya, G. Leontieva, Yu. Desheva, K. Grabovskaya, T. Gupalova, L. Rudenko, A. Suvorov

Research output: Contribution to journalArticlepeer-review

Abstract

Influenza and its bacterial complications are a leading cause of morbidity and mortality worldwide. The effect of combined immunization with live influenza vaccine and recombinant chimeric pneumococcal protein in dual infection caused by influenza H1N1 and S. pneumoniae (serotype 3) has been studied. The combined vaccine consisted of the strain A/California/2009/38 (H1N1) pdm and chimeric recombinant protein PSPF composed of immunodominant fragments of the surface virulence factors of S. pneumoniae—PsaA, PspA, and Shr1875—associated with modified salmonella flagellin. Vaccinated mice were infected with the influenza virus 24 hours before or 24 hours after the onset of pneumococcal infection. The protective effect of combined vaccination was shown on both models of viral-bacterial infection.
Original languageEnglish
Article number0222148
JournalPLoS ONE
Volume14
Issue number9
DOIs
StatePublished - 2019

Keywords

  • Animals
  • Antibodies, Bacterial/immunology
  • Antigens, Bacterial/immunology
  • Coinfection/prevention & control
  • Disease Models, Animal
  • Female
  • Flagellin/immunology
  • Influenza Vaccines/administration & dosage
  • Mice
  • Mice, Inbred BALB C
  • Pneumococcal Infections/prevention & control
  • Pneumococcal Vaccines/administration & dosage
  • Recombinant Proteins/administration & dosage
  • Treatment Outcome
  • Vaccination
  • Vaccines, Attenuated
  • Vaccines, Combined
  • Virulence Factors/immunology

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