Collapsed monomolecular thin films as surface nanomodification techniques for bioorganic MALDI analysis

E.S. Silyavka, A.A. Selyutin, N.G. Sukhodolov, V.V. Shilovskikh, P.A. Oleneva, A.A. Mitrofanov, O.A. Keltsieva, P.S. Dubakova, V.N. Babakov, M.L. Alexandrova, N.V. Krasnov, E.P. Podolskaya

Research outputpeer-review

Abstract

A modification method of the target for Matrix Assisted Laser Desorption/Ionization (MALDI) analysis by metal-affinity sorbents was proposed. Monolayers of metal stearates obtained in the geometry of the drop perform as such sorbents. The formation of monolayers was proved by optical microscopy and the Laser Desorption/Ionization (LDI) method. The surface of the substrate after modification studied using scanning electron microscopy. Metal-affinity extraction of human serum albumin adducts with soman was carried out at the modified target surface. MALDI mass spectrometric analysis demonstrated that signals corresponding to adducts are present in mass spectra.

Original languageEnglish
Title of host publicationInternational Conference on State-of-the-Art Trends of Scientific Research of Artificial and Natural Nanoobjects, STRANN 2018
PublisherAmerican Institute of Physics
ISBN (Print)9780735417922
DOIs
Publication statusPublished - 15 Jan 2019
EventInternational Conference on State-of-the-Art Trends of Scientific Research of Artificial and Natural Nanoobjects, STRANN 2018 - Moscow
Duration: 17 Oct 201819 Oct 2018

Publication series

NameAIP Conference Proceedings
PublisherAmerican Institute of Physics
Number1
Volume2064
ISSN (Print)0094-243X

Conference

ConferenceInternational Conference on State-of-the-Art Trends of Scientific Research of Artificial and Natural Nanoobjects, STRANN 2018
CountryRussian Federation
CityMoscow
Period17/10/1819/10/18

Scopus subject areas

  • Physics and Astronomy(all)

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    Silyavka, E. S., Selyutin, A. A., Sukhodolov, N. G., Shilovskikh, V. V., Oleneva, P. A., Mitrofanov, A. A., Keltsieva, O. A., Dubakova, P. S., Babakov, V. N., Alexandrova, M. L., Krasnov, N. V., & Podolskaya, E. P. (2019). Collapsed monomolecular thin films as surface nanomodification techniques for bioorganic MALDI analysis. In International Conference on State-of-the-Art Trends of Scientific Research of Artificial and Natural Nanoobjects, STRANN 2018 [030015] (AIP Conference Proceedings; Vol. 2064, No. 1). American Institute of Physics. https://doi.org/10.1063/1.5087677