Research output: Contribution to journal › Article › peer-review
Chitosan and chitosan nanofibers in wound dressings, from material preparation to functional design: A review. / Wang, Xiaoke ; Shan, Cancan ; Huang, Renliang ; Пенькова, Анастасия Владимировна; Su, Rongxin.
In: International Journal of Biological Macromolecules, Vol. 333, No. 2, 148937, 09.11.2025.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Chitosan and chitosan nanofibers in wound dressings, from material preparation to functional design: A review
AU - Wang, Xiaoke
AU - Shan, Cancan
AU - Huang, Renliang
AU - Пенькова, Анастасия Владимировна
AU - Su, Rongxin
PY - 2025/11/9
Y1 - 2025/11/9
N2 - Chitosan, a naturally derived cationic polysaccharide, and its nanoscale derivative, chitosan nanofibers (ChNFs), have emerged as promising biomaterials for wound dressing applications due to their intrinsic biocompatibility, biodegradability, and broad-spectrum antimicrobial activity. This review provides a comprehensive overview of recent advances in the preparation, modification, and application of chitosan and chitosan nanofibers for wound care. In this review, we first summarize the various origins of chitosan and the preparation methods of ChNFs. Next, we elaborate on various modification strategies for chitosan and ChNFs, such as quaternization, carboxymethylation, and N,N,N-trimethylation. Additionally, fabrication techniques for chitosan and ChNFs based wound dressings, such as electrospinning, solution blow spinning (SBS), microfluidic blow spinning (MBS), and 3D bioprinting, are discussed. The review highlights the applications of chitosan and ChNFs in wound dressings, including hemostasis, diabetic ulcer treatment, burn wound healing, with a special focus on and stimuli-responsive wound dressings. Finally, we address current challenges and propose future directions for enhancing the performance of chitosan and ChNFs based wound healing materials. This review aims to provide a theoretical insights and practical guidance for the next generation of high-performance chitosan-based wound dressings.
AB - Chitosan, a naturally derived cationic polysaccharide, and its nanoscale derivative, chitosan nanofibers (ChNFs), have emerged as promising biomaterials for wound dressing applications due to their intrinsic biocompatibility, biodegradability, and broad-spectrum antimicrobial activity. This review provides a comprehensive overview of recent advances in the preparation, modification, and application of chitosan and chitosan nanofibers for wound care. In this review, we first summarize the various origins of chitosan and the preparation methods of ChNFs. Next, we elaborate on various modification strategies for chitosan and ChNFs, such as quaternization, carboxymethylation, and N,N,N-trimethylation. Additionally, fabrication techniques for chitosan and ChNFs based wound dressings, such as electrospinning, solution blow spinning (SBS), microfluidic blow spinning (MBS), and 3D bioprinting, are discussed. The review highlights the applications of chitosan and ChNFs in wound dressings, including hemostasis, diabetic ulcer treatment, burn wound healing, with a special focus on and stimuli-responsive wound dressings. Finally, we address current challenges and propose future directions for enhancing the performance of chitosan and ChNFs based wound healing materials. This review aims to provide a theoretical insights and practical guidance for the next generation of high-performance chitosan-based wound dressings.
KW - Chitosan
KW - Chitosan nanofibers
KW - Functional modification
KW - Wound dressings
UR - https://www.mendeley.com/catalogue/0b25fbeb-7f02-3804-bb39-8808a7cd3028/
U2 - 10.1016/j.ijbiomac.2025.148937
DO - 10.1016/j.ijbiomac.2025.148937
M3 - Article
VL - 333
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
SN - 0141-8130
IS - 2
M1 - 148937
ER -
ID: 143781726