Childhood lymphoblastic leukemia adverse drug reactions: Study of risk factors and therapy prognosis by optical methods

A. Zyubin, A. Lavrova, S. Babak, V. Malaschenko, A. Borisova, N. Opryshko

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

The treatment of acute lymphoblastic leukemia (ALL) can result in the side-effects such as kidney affection, hepatic failure and tissue hypoxia. We study dynamics of special biochemical marker of these pathologies - adenosine triphosphate, that is well-known substance of energy metabolism. We use methods of confocal microscopy for determining the cellular and mitochondrial concentration of adenosine triphosphate (ATP). Quantitative values of adenosine triphosphate were calculated for each patient and correlation with degree of side-effects had been done. The application of confocal microscopy for studying of side-effects and therapy of lymphoblastic leukemia is discussed.

Original languageEnglish
Title of host publicationOptics in Health Care and Biomedical Optics VII
PublisherSPIE
Volume10024
ISBN (Electronic)9781510604674
DOIs
StatePublished - 1 Jan 2016
Externally publishedYes
EventOptics in Health Care and Biomedical Optics VII - Beijing, China
Duration: 11 Oct 201613 Oct 2016

Conference

ConferenceOptics in Health Care and Biomedical Optics VII
CountryChina
CityBeijing
Period11/10/1613/10/16

Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Keywords

  • acute leukemia
  • ATP.
  • child
  • confocal microscopy

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