Characterization of missense mutations in the SUP45 gene of Saccharomyces cerevisiae encoding translation termination factor eRF1

S. E. Moskalenko, G. A. Zhouravleva, M. Y. Soom, S. V. Chabelskaya, K. V. Volkov, O. M. Zemlyanko, M. Philippe, L. N. Mironova, S. G. Inge-Vechtomov

Research output

4 Citations (Scopus)

Abstract

Collection of missense mutations in the SUP45 gene of Saccharomyces cerevisiae encoding translation termination factor eRF1 has been obtained by different approaches. It has been shown that most of isolated mutations cause amino acid substitutions in the N-terminal part of eRF1 and do not decrease the eRF1 amount. Most of mutations studied do not abolish eRF1-eRF3 interaction. The role of the N-terminal part of eRF1 in stop codon recognition is discussed.

Original languageEnglish
Pages (from-to)478-484
Number of pages7
JournalRussian Journal of Genetics
Volume40
Issue number5
DOIs
Publication statusPublished - 1 May 2004

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Missense Mutation
Saccharomyces cerevisiae
Mutation
Terminator Codon
Amino Acid Substitution
Genes

Scopus subject areas

  • Genetics

Cite this

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title = "Characterization of missense mutations in the SUP45 gene of Saccharomyces cerevisiae encoding translation termination factor eRF1",
abstract = "Collection of missense mutations in the SUP45 gene of Saccharomyces cerevisiae encoding translation termination factor eRF1 has been obtained by different approaches. It has been shown that most of isolated mutations cause amino acid substitutions in the N-terminal part of eRF1 and do not decrease the eRF1 amount. Most of mutations studied do not abolish eRF1-eRF3 interaction. The role of the N-terminal part of eRF1 in stop codon recognition is discussed.",
author = "Moskalenko, {S. E.} and Zhouravleva, {G. A.} and Soom, {M. Y.} and Chabelskaya, {S. V.} and Volkov, {K. V.} and Zemlyanko, {O. M.} and M. Philippe and Mironova, {L. N.} and Inge-Vechtomov, {S. G.}",
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T1 - Characterization of missense mutations in the SUP45 gene of Saccharomyces cerevisiae encoding translation termination factor eRF1

AU - Moskalenko, S. E.

AU - Zhouravleva, G. A.

AU - Soom, M. Y.

AU - Chabelskaya, S. V.

AU - Volkov, K. V.

AU - Zemlyanko, O. M.

AU - Philippe, M.

AU - Mironova, L. N.

AU - Inge-Vechtomov, S. G.

PY - 2004/5/1

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AB - Collection of missense mutations in the SUP45 gene of Saccharomyces cerevisiae encoding translation termination factor eRF1 has been obtained by different approaches. It has been shown that most of isolated mutations cause amino acid substitutions in the N-terminal part of eRF1 and do not decrease the eRF1 amount. Most of mutations studied do not abolish eRF1-eRF3 interaction. The role of the N-terminal part of eRF1 in stop codon recognition is discussed.

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