Chapter 5.1 Microdialysis in genetically altered animals

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

1 Scopus citations

Abstract

Recent advances in genetic approaches significantly extended horizon of opportunities to manipulate with expression of mammalian genes in vivo resulting in development of thousands of mouse strains carrying specific genetic alterations. Microdialysis shows a great utility to analyze consequences of such genetic manipulations on the processes governing synthesis, release, uptake, and neurotransmitter interactions in a physiologically or behaviorally relevant context. In this review, a history of microdialysis in mutant animals, practical considerations of microdialysis applications in mouse genetic models, and several examples of such applications are discussed. With the increasing power and fidelity of genetic manipulations and the development of uncountable number of various mutant mice, an explosion of studies using microdialysis in genetic models could be expected.

Original languageEnglish
Title of host publicationHandbook of Microdialysis Methods, Applications and Perspectives
EditorsBen Westerink, Thomas Cremers
Pages399-417
Number of pages19
DOIs
StatePublished - 1 Dec 2006
Externally publishedYes

Publication series

NameHandbook of Behavioral Neuroscience
Volume16
ISSN (Print)1569-7339

Scopus subject areas

  • Cognitive Neuroscience
  • Behavioral Neuroscience

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