3 Citations (Scopus)

Abstract

Centrosomes are the major centre of microtubule nucleation and microtubule minus-ends concentration in animal cells. Microtubule plus-ends are directed to a nucleus and chromosomes or to a cell cortex. The crossing of signal transduction pathways and the network of interactions between signal molecules controlling cell cycle are revealed in centrosomes. The ability of centrosomes for reduplication suggests the existence of hypothetic template elements. It is attractive to suggest the essential role of specific centrosome-associated RNAs in biogenesis of centrosomes. Untranslated RNAs playing a structural role and mRNAs that are localized in centrosomes to regulate protein synthesis in close proximity to mitotic apparatus may be present among these RNAs. Centrosomes positioning plays the important role in determining of cell polarity. Centrosomes are critical for the formation and support of cilia and flagella having motility or sensory functions.

Original languageEnglish
Pages (from-to)5-17
Number of pages13
JournalTsitologiya
Volume50
Issue number1
Publication statusPublished - 28 Mar 2008

Fingerprint

Centrosome
Brain
Microtubules
RNA
Cell Polarity
Untranslated RNA
Spindle Apparatus
Aptitude
Flagella
Cilia
Signal Transduction
Cell Cycle
Chromosomes
Messenger RNA

Scopus subject areas

  • Histology

Cite this

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title = "Centrosome as «a brain» of an animal cell",
abstract = "Centrosomes are the major centre of microtubule nucleation and microtubule minus-ends concentration in animal cells. Microtubule plus-ends are directed to a nucleus and chromosomes or to a cell cortex. The crossing of signal transduction pathways and the network of interactions between signal molecules controlling cell cycle are revealed in centrosomes. The ability of centrosomes for reduplication suggests the existence of hypothetic template elements. It is attractive to suggest the essential role of specific centrosome-associated RNAs in biogenesis of centrosomes. Untranslated RNAs playing a structural role and mRNAs that are localized in centrosomes to regulate protein synthesis in close proximity to mitotic apparatus may be present among these RNAs. Centrosomes positioning plays the important role in determining of cell polarity. Centrosomes are critical for the formation and support of cilia and flagella having motility or sensory functions.",
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Centrosome as «a brain» of an animal cell. / Mamon, L. A.

In: Tsitologiya, Vol. 50, No. 1, 28.03.2008, p. 5-17.

Research output

TY - JOUR

T1 - Centrosome as «a brain» of an animal cell

AU - Mamon, L. A.

PY - 2008/3/28

Y1 - 2008/3/28

N2 - Centrosomes are the major centre of microtubule nucleation and microtubule minus-ends concentration in animal cells. Microtubule plus-ends are directed to a nucleus and chromosomes or to a cell cortex. The crossing of signal transduction pathways and the network of interactions between signal molecules controlling cell cycle are revealed in centrosomes. The ability of centrosomes for reduplication suggests the existence of hypothetic template elements. It is attractive to suggest the essential role of specific centrosome-associated RNAs in biogenesis of centrosomes. Untranslated RNAs playing a structural role and mRNAs that are localized in centrosomes to regulate protein synthesis in close proximity to mitotic apparatus may be present among these RNAs. Centrosomes positioning plays the important role in determining of cell polarity. Centrosomes are critical for the formation and support of cilia and flagella having motility or sensory functions.

AB - Centrosomes are the major centre of microtubule nucleation and microtubule minus-ends concentration in animal cells. Microtubule plus-ends are directed to a nucleus and chromosomes or to a cell cortex. The crossing of signal transduction pathways and the network of interactions between signal molecules controlling cell cycle are revealed in centrosomes. The ability of centrosomes for reduplication suggests the existence of hypothetic template elements. It is attractive to suggest the essential role of specific centrosome-associated RNAs in biogenesis of centrosomes. Untranslated RNAs playing a structural role and mRNAs that are localized in centrosomes to regulate protein synthesis in close proximity to mitotic apparatus may be present among these RNAs. Centrosomes positioning plays the important role in determining of cell polarity. Centrosomes are critical for the formation and support of cilia and flagella having motility or sensory functions.

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KW - Microtubules

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