Calliphoridae Flies in Medical Biotechnology

Research output

Abstract

Blow flies (Diptera, Calliphoridae) and their medical applications have attracted the attention of biologists and doctors for more than a century. The best known is the use of “surgical maggots” in the treatment of infected wounds and ulcers. Another promising direction is the use of Calliphoridae as producers of pharmacologically active substances. Compounds with antiviral and antitumor activity isolated from blow fly maggots have found application in the treatment of viral infections. The maggot enzymes and antimicrobial peptides are another group of drug candidates that have received much attention. This review summarizes information on Calliphoridae as a source of new drugs and the prospects for their use in solving the urgent problems of modern medicine, such as the growing antibiotic resistance of pathogens, the treatment of viral infections and cancerous diseases.

Original languageEnglish
Pages (from-to)292-301
JournalEntomological Review
Volume99
Issue number3
DOIs
Publication statusPublished - 1 Jun 2019

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Calliphoridae
biotechnology
insect larvae
wound treatment
new drugs
antimicrobial peptides
physicians
antibiotic resistance
infection
biologists
medicine
drugs
pathogens
enzymes

Scopus subject areas

  • Insect Science

Cite this

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abstract = "Blow flies (Diptera, Calliphoridae) and their medical applications have attracted the attention of biologists and doctors for more than a century. The best known is the use of “surgical maggots” in the treatment of infected wounds and ulcers. Another promising direction is the use of Calliphoridae as producers of pharmacologically active substances. Compounds with antiviral and antitumor activity isolated from blow fly maggots have found application in the treatment of viral infections. The maggot enzymes and antimicrobial peptides are another group of drug candidates that have received much attention. This review summarizes information on Calliphoridae as a source of new drugs and the prospects for their use in solving the urgent problems of modern medicine, such as the growing antibiotic resistance of pathogens, the treatment of viral infections and cancerous diseases.",
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Calliphoridae Flies in Medical Biotechnology. / Yakovlev, A.Yu.; Kruglikova, A.A.; Chernysh, S.I.

In: Entomological Review, Vol. 99, No. 3, 01.06.2019, p. 292-301.

Research output

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