Calculation of the association constants of polynucleotides in solutions

Research output

13 Citations (Scopus)

Abstract

A mathematical analysis of the titration data for the ideal polymer containing a periodically repeating functional group capable of reversibly attaching ligands in solution was performed. The titration curves were described by applying a matrix method to calculate the equilibrium constant of polymer complex formation. The results of mathematical modeling were compared with experimental data. On this basis, the concentration dependence of the equilibrium constant for the deprotonation of a synthetic poly(ribouridylic acid) in aqueous solution was proposed.

Original languageEnglish
Pages (from-to)527-532
Number of pages6
JournalPolymer Science - Series A
Volume42
Issue number5
Publication statusPublished - 1 May 2000

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Polynucleotides
Equilibrium constants
Titration
Polymers
Association reactions
Deprotonation
Functional groups
Ligands
Acids

Scopus subject areas

  • Polymers and Plastics
  • Materials Chemistry

Cite this

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abstract = "A mathematical analysis of the titration data for the ideal polymer containing a periodically repeating functional group capable of reversibly attaching ligands in solution was performed. The titration curves were described by applying a matrix method to calculate the equilibrium constant of polymer complex formation. The results of mathematical modeling were compared with experimental data. On this basis, the concentration dependence of the equilibrium constant for the deprotonation of a synthetic poly(ribouridylic acid) in aqueous solution was proposed.",
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