Calcium-mediated one-pot preparation of isoxazoles with deuterium incorporation

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30 Scopus citations


In this work, a novel synthetic methodology for the one-pot preparation of isoxazoles directly from the reaction of calcium carbide with aldoximes is reported. Calcium carbide acts as a safe and inexpensive acetylene source and, in addition, as a source of the Ca(OH)2 base to enable the generation of nitrile oxide. Various 3-substituted isoxazoles were synthesized from the corresponding aldoximes in good yields (up to 95%) and a series of new deuterated 4,5-dideuteroisoxazoles were prepared.

Original languageEnglish
Pages (from-to)226-231
Number of pages6
JournalOrganic Chemistry Frontiers
Issue number2
StatePublished - 21 Jan 2018

Scopus subject areas

  • Organic Chemistry


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