Biomedical applications of capillary electrophoresis

Research output

6 Citations (Scopus)

Abstract

© 2015 Russian Academy of Sciences and Turpion Ltd.The review deals with modern analytical approaches used in capillary electrophoresis for solving medical and biological problems: search for biomarkers of various diseases and rapid diagnosis based on characteristic profiles of biologically active compounds by capillary electrophoresis with mass spectrometric detection; monitoring of the residual drugs in biological fluids for evaluating the efficiency of drug therapy; testing of the enantiomeric purity of pharmaceutical products; the use of novel materials as components of stationary and pseudo-stationary phases in capillary electrophoresis and capillary electrochromatography to increase the selectivity of separation of components of complex matrices; and identification of various on-line preconcentration techniques to reduce the detection limits of biologically active analytes. A topical trend in capillary electrophoresis required in clinical practice, viz., the design of microfluidic systems, is discussed.
Original languageEnglish
Pages (from-to)860-874
JournalRussian Chemical Reviews
Issue number8
DOIs
Publication statusPublished - 2015

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