Beta and gamma human papillomaviruses in anal and genital sites among men: Prevalence and determinants

Vitaly Smelov, Richard Muwonge, Olga Sokolova, Sandrine McKay-Chopin, Carina Eklund, Boris Komyakov, Tarik Gheit

Research output

6 Citations (Scopus)

Abstract

Data regarding the anogenital distribution of and type-specific concordance for cutaneous β- and γ-HPV types in men who have sex with women is limited and geographically narrow. Knowledge of determinants of anogenital detection of cutaneous HPV types in different regions is needed for better understanding of the natural history and transmission dynamics of HPV, and its potential role in the development of anogenital diseases. Genital and anal canal samples obtained from 554 Russian men were screened for 43 β-HPVs and 29 γ-HPVs, using a multiplex PCR combined with Luminex technology. Both β- and γ-HPVs were more prevalent in the anal (22.8% and 14.1%) samples than in the genital (16.8% and 12.3%) samples. Low overall and type-specific concordance for β-HPVs (3.5% and 1.1%) and γ-HPVs (1.3% and 0.6%) were observed between genital and anal samples. HIV-positive men had higher anal β- (crude OR = 12.2, 95% CI: 5.3-28.1) and γ-HPV (crude OR = 7.2, 95% CI: 3.3-15.4) prevalence than HIV-negative men. Due to the lack of genital samples from the HIV-positive men, no comparison was possible for HIV status in genital samples. The lack of type-specific positive concordance between genital and anal sites for cutaneous β- and γ-HPV types in heterosexual men posits the needs for further studies on transmission routes to discriminate between contamination and true HPV infection. HIV-positive status may favor the anal acquisition or modify the natural history of cutaneous HPV types.

Original languageEnglish
Article number8241
JournalScientific Reports
Volume8
Issue number1
DOIs
Publication statusPublished - 1 Dec 2018

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HIV
Skin
Natural History
Multiplex Polymerase Chain Reaction
Heterosexuality
Anal Canal
Technology
Infection

Scopus subject areas

  • General

Cite this

Smelov, Vitaly ; Muwonge, Richard ; Sokolova, Olga ; McKay-Chopin, Sandrine ; Eklund, Carina ; Komyakov, Boris ; Gheit, Tarik. / Beta and gamma human papillomaviruses in anal and genital sites among men : Prevalence and determinants. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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abstract = "Data regarding the anogenital distribution of and type-specific concordance for cutaneous β- and γ-HPV types in men who have sex with women is limited and geographically narrow. Knowledge of determinants of anogenital detection of cutaneous HPV types in different regions is needed for better understanding of the natural history and transmission dynamics of HPV, and its potential role in the development of anogenital diseases. Genital and anal canal samples obtained from 554 Russian men were screened for 43 β-HPVs and 29 γ-HPVs, using a multiplex PCR combined with Luminex technology. Both β- and γ-HPVs were more prevalent in the anal (22.8{\%} and 14.1{\%}) samples than in the genital (16.8{\%} and 12.3{\%}) samples. Low overall and type-specific concordance for β-HPVs (3.5{\%} and 1.1{\%}) and γ-HPVs (1.3{\%} and 0.6{\%}) were observed between genital and anal samples. HIV-positive men had higher anal β- (crude OR = 12.2, 95{\%} CI: 5.3-28.1) and γ-HPV (crude OR = 7.2, 95{\%} CI: 3.3-15.4) prevalence than HIV-negative men. Due to the lack of genital samples from the HIV-positive men, no comparison was possible for HIV status in genital samples. The lack of type-specific positive concordance between genital and anal sites for cutaneous β- and γ-HPV types in heterosexual men posits the needs for further studies on transmission routes to discriminate between contamination and true HPV infection. HIV-positive status may favor the anal acquisition or modify the natural history of cutaneous HPV types.",
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Beta and gamma human papillomaviruses in anal and genital sites among men : Prevalence and determinants. / Smelov, Vitaly; Muwonge, Richard; Sokolova, Olga; McKay-Chopin, Sandrine; Eklund, Carina; Komyakov, Boris; Gheit, Tarik.

In: Scientific Reports, Vol. 8, No. 1, 8241, 01.12.2018.

Research output

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AU - Smelov, Vitaly

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AU - Sokolova, Olga

AU - McKay-Chopin, Sandrine

AU - Eklund, Carina

AU - Komyakov, Boris

AU - Gheit, Tarik

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