Autoimmunity in acute ischemic stroke and the role of blood-brain barrier: the dark side or the light one?

Nikolay V. Tsygan, Alexandr P. Trashkov, Igor V. Litvinenko, Viktoriya A. Yakovleva, Alexandr V. Ryabtsev, Andrey G. Vasiliev, Leonid P. Churilov

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Abstract

This article presents a synopsis of the current data on the mechanisms of blood-brain barrier (BBB) alteration and autoimmune response in acute ischemic stroke. Most researchers confirm the relationship between the severity of immunobiochemical changes and clinical outcome of acute ischemic stroke. Ischemic stroke is accompanied by aseptic inflammation, which alters the brain tissue and exposes the co-stimulatory molecules of the immune system and the neuronal antigens. To date, BBB is not considered the border between the immune system and central nervous system, and the local immune subsystems are found within and behind the BBB. BBB disruption contributes to the leakage of brain autoantigens and induction of secondary autoimmune response to neuronal antigens and long-term inflammation. Glymphatic system function is altered and jeopardized both in hemorrhagic and ischemic stroke types. The receptors of innate immunity (toll-like receptor-2 and toll-like receptor-4) are also involved in acute ischemia-reperfusion injury. Immune response is related to the key processes of blood clotting and fibrinolysis. At the same time, the stroke-induced immune activation may promote reparation phenomena in the brain. Subsequent research on the reduction of the acute ischemic brain injury through the target regulation of the immune response is promising.

Original languageEnglish
Pages (from-to)420-426
Number of pages7
JournalFrontiers of Medicine
Volume13
Issue number4
DOIs
Publication statusPublished - 1 Aug 2019
EventWu Lien-Teh Forum. The 5th China-Russia International Conference on Microbiology, Immunology and Related Diseases - Harbin Medical University, Harbin
Duration: 23 Jan 201725 Jan 2018
Conference number: 5

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Blood-Brain Barrier
Autoimmunity
Stroke
Light
Immune System
Brain
Inflammation
Antigens
Toll-Like Receptor 2
Toll-Like Receptor 4
Autoantigens
Blood Coagulation
Fibrinolysis
Reperfusion Injury
Innate Immunity
Brain Injuries
Central Nervous System
Research Personnel
Research

Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

Cite this

Tsygan, Nikolay V. ; Trashkov, Alexandr P. ; Litvinenko, Igor V. ; Yakovleva, Viktoriya A. ; Ryabtsev, Alexandr V. ; Vasiliev, Andrey G. ; Churilov, Leonid P. . / Autoimmunity in acute ischemic stroke and the role of blood-brain barrier : the dark side or the light one?. In: Frontiers of Medicine. 2019 ; Vol. 13, No. 4. pp. 420-426.
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Autoimmunity in acute ischemic stroke and the role of blood-brain barrier : the dark side or the light one? / Tsygan, Nikolay V. ; Trashkov, Alexandr P. ; Litvinenko, Igor V. ; Yakovleva, Viktoriya A. ; Ryabtsev, Alexandr V. ; Vasiliev, Andrey G. ; Churilov, Leonid P. .

In: Frontiers of Medicine, Vol. 13, No. 4, 01.08.2019, p. 420-426.

Research output

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AU - Trashkov, Alexandr P.

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AU - Yakovleva, Viktoriya A.

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