Autoimmune thyroiditis: Centennial jubilee of a social disease and its comorbidity

L.P. Churilov, Y.I. Stroev, I.Y Serdyuk, O.M. Kaminova-Mudzhikova, I.V. Belyaeva, A.N. Gvozdetsky, N.A. Nitsa, L.R. Mikhailova

Research output

4 Citations (Scopus)

Abstract

The history of autoimmune thyroiditis (AIT) and its role in pathophysiology of transition from adolescent hypothalamic syndrome (obesity with rose striae) into early metabolic syndrome is reviewed. Marfanoid phenotype and chronic disequilibrium between local, autacoid-mediated and systemic, hormone-mediated regulation, typical for inherited connective tissue disorders, may promote this transition. Pathogenetic roles of hyperprolactinemia and cytokine misbalance are evaluated and discussed in its pathogenesis. © 2013 Elsevier Ireland Ltd.
Original languageEnglish
Pages (from-to)135-145
JournalPathophysiology
Volume21
Issue number2
DOIs
Publication statusPublished - 2014

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