Auditory environmental enrichment prevents anxiety-like behavior, but not cortisol responses, evoked by 24-h social isolation in zebrafish

Letícia Marchetto, Leonardo J. G. Barcellos, Gessi Koakoski, Suelen M. Soares, Aline Pompermaier, Victoria C Maffi, Roberta Costa, Carolina G. da Silva, Natalie R. Zorzi, Konstantin A Demin, Allan V. Kalueff, Heloisa H de Alcantara Barcellos

Research output: Contribution to journalArticlepeer-review

Abstract

The zebrafish (Danio rerio) is widely used as a promising translational model organism for studying various brain disorders. Zebrafish are also commonly used in behavioral and drug screening assays utilizing individually tested (socially isolated) fish. Various sounds emerge as important exogenous factors that may affect fish behavior. Mounting evidence shows that musical/auditory environmental enrichment can improve welfare of laboratory animals, including fishes. Here, we show that auditory environmental enrichment mitigates anxiogenic-like effects caused by acute social isolation in adult zebrafish. Thus, auditory environmental enrichment may offer an inexpensive, feasible and simple tool to improve welfare of zebrafish stocks in laboratory facilities, reduce unwanted procedural stress, lower non-specific behavioral variance and, hence, collectively improve zebrafish data reliability and reproducibility.

Original languageEnglish
Article number113169
Pages (from-to)113169
Number of pages7
JournalBehavioural Brain Research
Volume404
Early online date9 Feb 2021
DOIs
StatePublished - 23 Apr 2021

Scopus subject areas

  • Behavioral Neuroscience

Keywords

  • Anxiety-like behavior
  • Auditory environmental enrichment
  • Refinement
  • Social behavior
  • Stress
  • Zebrafish
  • DISORDERS
  • MUSIC-THERAPY
  • ANIMAL-MODELS
  • GENERATION
  • NEUROSCIENCE RESEARCH
  • STRESS
  • BENEFITS
  • BRAIN
  • EXPOSURE

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