ATP concentration as possible marker of liver damage at leukaemia treatment: Confocal microscopy-based experimental study and numerical simulations

V. Malashchenko, A. Zyubin, S. Babak, A. Lavrova

Research output: Chapter in Book/Report/Conference proceedingConference contributionResearchpeer-review

Abstract

We consider the method of confocal microscopy as a convenient instrument for determination of chemical compounds in biological tissues and cells. In particular, we study the dynamics of adenosine triphosphate (ATP) concentration that could be used as a bio-marker of energy metabolism pathologies at the treatment of acute lymphoblastic leukaemia (ALL). On the basis of data obtained by the confocal microscopy, the values of ATP concentration have been calculated for each case. Possible correlations with other characteristics of pathology processes obtained from plasma of leukemia patients show that ATP value could be a prognostic factor of the treatment success. The role of ATP in the drug metabolism switching is also discussed within the context of kinetic modelling of metabolism processes leading to the production of 6-Thioguanosine monophosphate, which is a principal acting agent in chemotherapy.

Original languageEnglish
Title of host publicationSaratov Fall Meeting 2016
Subtitle of host publicationLaser Physics and Photonics XVII; and Computational Biophysics and Analysis of Biomedical Data III
PublisherSPIE
Volume10337
ISBN (Electronic)9781510611191
DOIs
StatePublished - 1 Jan 2017
Externally publishedYes
Event4th International Symposium on Optics and Biophotonics, SFM 2016 - Saratov, Russian Federation
Duration: 26 Sep 201629 Sep 2016

Conference

Conference4th International Symposium on Optics and Biophotonics, SFM 2016
CountryRussian Federation
CitySaratov
Period26/09/1629/09/16

Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Keywords

  • acute lymphoblastic leukemia
  • adenosine triphosphate concentration
  • confocal microscopy
  • numeri-cal simulations

Fingerprint Dive into the research topics of 'ATP concentration as possible marker of liver damage at leukaemia treatment: Confocal microscopy-based experimental study and numerical simulations'. Together they form a unique fingerprint.

Cite this