Association between endothelial dysfunction and depression-like symptoms in chronic mild stress model of depression

Elena V. Bouzinova, Rikke Norregaard, Donna M.B. Boedtkjer, Irina A. Razgovorova, Anaïs M.J. Moeller, Olga Kudryavtseva, Ove Wiborg, Christian Aalkjaer, Vladimir V. Matchkov

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Objective: Cardiovascular diseases have high comorbidity with major depression. Endothelial dysfunction may explain the adverse cardiovascular outcome in depression; therefore, we analyzed it in vitro. In the chronic mild stress model, some rats develop depression-like symptoms (including “anhedonia”), whereas others are stress resilient. Methods: After 8 weeks of chronic mild stress, anhedonic rats reduced their sucrose intake by 55% (7%), whereas resilient rats did not. Acetylcholine-induced endothelium-dependent relaxation of norepinephrine-preconstricted mesenteric arteries was analyzed in nonstressed, anhedonic, and resilient rat groups. Results: Small resistance arteries from anhedonic rats were less sensitive to acetylcholine than those of the nonstressed and resilient groups (p = .029). Pathways of endothelium-dependent relaxation were altered in arteries from anhedonic rats. Nitric oxide (NO)–dependent relaxation and endothelial NO synthase expression were increased in arteries from anhedonic rats
Original languageEnglish
Pages (from-to)268–276
JournalPsychosomatic Medicine
Volume76
Issue number4
DOIs
StatePublished - 2014

Keywords

  • major depression
  • chronic mild stress
  • cyclooxygenase
  • endothelium-dependent hyperpolarization
  • nitric oxide
  • resistance arteries

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