Apicomplexan-like parasites are polyphyletic and widely but selectively dependent on cryptic plastid organelles.

Jan Janouškovec, Gita G. Paskerova, Tatiana S. Miroliubova, Kirill V. Mikhailov, Thomas Birley, Vladimir V. Aleoshin, Timur G. Simdyanov

Research output

Abstract

The phylum Apicomplexa comprises human pathogens such as Plasmodium but are also an under-explored hotspot of evolutionary diversity central to understanding the origins of parasitism and non-photosynthetic plastids. We generated single-cell transcriptomes for all major apicomplexan groups lacking large-scale sequence data. Phylogenetic analysis reveals that apicomplexan-like parasites are polyphyletic and their similar morphologies emerged convergently at least three times. Gregarines and eugregarines are monophyletic, against most expectations, and rhytidocystids and Eleutheroschizon are sister lineages to medically important taxa. Although previously unrecognized, plastids in deep-branching apicomplexans are common, and they contain some of the most divergent and AT-rich genomes ever found. In eugregarines, however, plastids are either abnormally reduced or absent, thus increasing known plastid losses in eukaryotes from two to four. Environmental sequences of ten novel plastid lineages and structural innovations in plastid proteins confirm that plastids in apicomplexans and their relatives are widespread and share a common, photosynthetic origin.
Original languageEnglish
Article number49662
Number of pages24
JournaleLife
Volume8
Early online date16 Aug 2019
DOIs
Publication statusPublished - 16 Aug 2019

Fingerprint

Chloroplast Proteins
Plastids
plastid
Pathogens
Organelles
parasite
Parasites
Genes
Innovation
Apicoplasts
Apicomplexa
Plasmodium
Eukaryota
Transcriptome
eukaryote
Genome
parasitism
innovation
genome
pathogen

Scopus subject areas

  • Environmental Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Janouškovec, Jan ; Paskerova, Gita G. ; Miroliubova, Tatiana S. ; Mikhailov, Kirill V. ; Birley, Thomas ; Aleoshin, Vladimir V. ; Simdyanov, Timur G. / Apicomplexan-like parasites are polyphyletic and widely but selectively dependent on cryptic plastid organelles. In: eLife. 2019 ; Vol. 8.
@article{b109903c1e0e4ca4936c9f4299705c34,
title = "Apicomplexan-like parasites are polyphyletic and widely but selectively dependent on cryptic plastid organelles.",
abstract = "The phylum Apicomplexa comprises human pathogens such as Plasmodium but are also an under-explored hotspot of evolutionary diversity central to understanding the origins of parasitism and non-photosynthetic plastids. We generated single-cell transcriptomes for all major apicomplexan groups lacking large-scale sequence data. Phylogenetic analysis reveals that apicomplexan-like parasites are polyphyletic and their similar morphologies emerged convergently at least three times. Gregarines and eugregarines are monophyletic, against most expectations, and rhytidocystids and Eleutheroschizon are sister lineages to medically important taxa. Although previously unrecognized, plastids in deep-branching apicomplexans are common, and they contain some of the most divergent and AT-rich genomes ever found. In eugregarines, however, plastids are either abnormally reduced or absent, thus increasing known plastid losses in eukaryotes from two to four. Environmental sequences of ten novel plastid lineages and structural innovations in plastid proteins confirm that plastids in apicomplexans and their relatives are widespread and share a common, photosynthetic origin.",
author = "Jan Janouškovec and Paskerova, {Gita G.} and Miroliubova, {Tatiana S.} and Mikhailov, {Kirill V.} and Thomas Birley and Aleoshin, {Vladimir V.} and Simdyanov, {Timur G.}",
year = "2019",
month = "8",
day = "16",
doi = "10.7554/eLife.49662",
language = "English",
volume = "8",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications",

}

Apicomplexan-like parasites are polyphyletic and widely but selectively dependent on cryptic plastid organelles. / Janouškovec, Jan; Paskerova, Gita G. ; Miroliubova, Tatiana S. ; Mikhailov, Kirill V.; Birley, Thomas; Aleoshin, Vladimir V.; Simdyanov, Timur G.

In: eLife, Vol. 8, 49662, 16.08.2019.

Research output

TY - JOUR

T1 - Apicomplexan-like parasites are polyphyletic and widely but selectively dependent on cryptic plastid organelles.

AU - Janouškovec, Jan

AU - Paskerova, Gita G.

AU - Miroliubova, Tatiana S.

AU - Mikhailov, Kirill V.

AU - Birley, Thomas

AU - Aleoshin, Vladimir V.

AU - Simdyanov, Timur G.

PY - 2019/8/16

Y1 - 2019/8/16

N2 - The phylum Apicomplexa comprises human pathogens such as Plasmodium but are also an under-explored hotspot of evolutionary diversity central to understanding the origins of parasitism and non-photosynthetic plastids. We generated single-cell transcriptomes for all major apicomplexan groups lacking large-scale sequence data. Phylogenetic analysis reveals that apicomplexan-like parasites are polyphyletic and their similar morphologies emerged convergently at least three times. Gregarines and eugregarines are monophyletic, against most expectations, and rhytidocystids and Eleutheroschizon are sister lineages to medically important taxa. Although previously unrecognized, plastids in deep-branching apicomplexans are common, and they contain some of the most divergent and AT-rich genomes ever found. In eugregarines, however, plastids are either abnormally reduced or absent, thus increasing known plastid losses in eukaryotes from two to four. Environmental sequences of ten novel plastid lineages and structural innovations in plastid proteins confirm that plastids in apicomplexans and their relatives are widespread and share a common, photosynthetic origin.

AB - The phylum Apicomplexa comprises human pathogens such as Plasmodium but are also an under-explored hotspot of evolutionary diversity central to understanding the origins of parasitism and non-photosynthetic plastids. We generated single-cell transcriptomes for all major apicomplexan groups lacking large-scale sequence data. Phylogenetic analysis reveals that apicomplexan-like parasites are polyphyletic and their similar morphologies emerged convergently at least three times. Gregarines and eugregarines are monophyletic, against most expectations, and rhytidocystids and Eleutheroschizon are sister lineages to medically important taxa. Although previously unrecognized, plastids in deep-branching apicomplexans are common, and they contain some of the most divergent and AT-rich genomes ever found. In eugregarines, however, plastids are either abnormally reduced or absent, thus increasing known plastid losses in eukaryotes from two to four. Environmental sequences of ten novel plastid lineages and structural innovations in plastid proteins confirm that plastids in apicomplexans and their relatives are widespread and share a common, photosynthetic origin.

UR - https://www.ncbi.nlm.nih.gov/pubmed/31418692

U2 - 10.7554/eLife.49662

DO - 10.7554/eLife.49662

M3 - Article

VL - 8

JO - eLife

JF - eLife

SN - 2050-084X

M1 - 49662

ER -