Antimicrobial resistance of nosocomial strains of Staphylococcus aureus in Russia: Results of a prospective study

L. S. Stratchounski, A. V. Dekhnich, V. A. Kretchikov, I. A. Edelstain, A. D. Narezkina, G. E. Afinogenov, L. I. Akhmetova, L. G. Boronina, E. N. Gugutcidze, L. V. Gudkova, D. E. Zdzitovetcki, V. N. Ilyina, O. I. Kretchikova, N. E. Marusina, I. G. Multih, S. I. Pylaeva, I. V. Smirnov, T. N. Suborova, V. K. Taraban, N. M. FurletovaS. G. Hasanova, E. V. Schetinin

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

A total of 879 Staphylococcus aureus clinical isolates from 17 medical institutions in different regions of Russia were tested. Susceptibility to 18 antimicrobials was determined by agar dilution in accordance with the NCCLS recommendations. The most potent antimicrobials were glycopeptides, linezolid, and fusidic acid, to which no resistance was found. Other antimicrobials with low frequency of non-susceptibility were mupirocin (0.3%), trimethoprim/ sulfamethoxazole (0.8%), quinupristin/dalfopristin (1.8%) and rifampicin (7.0%). Fluoroquinolones displayed moderate activity (5.8% of non-susceptible strains to moxifloxacin, 9.1% to levofloxacin, 13.1% to ciprofloxacin). High rates of non-susceptibility were found to clindamycin (27.1%), gentamicin (30.7%), tetracycline (37.1%), erythromycin (39.6%) and chloramphenicol (43.1%). The prevalence of oxacillin-resistant S. aureus (ORSA) was 33.5% and varied from 0% to 89.5% in different hospitals. ORSA were isolated most frequently in the burn units (77.5%), intensive care units (54.8%), trauma and orthopedics units (42.1%). This is the first multicenter study published of antimicrobial resistance of S. aureus in Russia which meets international standards.

Original languageEnglish
Pages (from-to)54-60
Number of pages7
JournalJournal of Chemotherapy
Volume17
Issue number1
DOIs
StatePublished - Feb 2005

Scopus subject areas

  • Oncology
  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Keywords

  • Antimicrobial resistance
  • Nosocomial infections
  • Staphylococcus aureus

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