Research output: Contribution to journal › Article › peer-review
Antibacterial UV-Curable Gel with Hydroxyapatite Nanoparticles for Regenerative Medicine in the Field of Orthopedics. / Burunkova, Julia A.; Semykina, Valeria V.; Sitnikova, Vera E.; Dolgintsev, Dmitry M.; Zaripova, Faliya F.; Ponomareva, Alina A.; Mizina, Diana R.; Csick, Attila; Kokenyesi, Sandor; Zhilenkov, Anton.
In: Journal of Composites Science, Vol. 9, No. 2, 65, 01.02.2025.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Antibacterial UV-Curable Gel with Hydroxyapatite Nanoparticles for Regenerative Medicine in the Field of Orthopedics
AU - Burunkova, Julia A.
AU - Semykina, Valeria V.
AU - Sitnikova, Vera E.
AU - Dolgintsev, Dmitry M.
AU - Zaripova, Faliya F.
AU - Ponomareva, Alina A.
AU - Mizina, Diana R.
AU - Csick, Attila
AU - Kokenyesi, Sandor
AU - Zhilenkov, Anton
PY - 2025/2/1
Y1 - 2025/2/1
N2 - The development and analysis of the properties of a new material based on UV-curable acrylate monomers with silicon-containing hydroxyapatite and zinc oxide nanoparticles as an antibacterial component and gelatin was carried out. Using this material in orthopedics and dentistry is very convenient because it covers any surface geometry of metal implants and hardens under ultraviolet light. In this work, sorption properties, changes in porosity, and mechanical properties of the material were investigated. The conditions for obtaining hydroxyapatite (HA) nanoparticles and the presence of silicon oxide nanoparticles and organic for the shell in an aqueous medium were studied for the pH of the medium, the sequence of administration and concentration of the material components, as well as antibacterial properties. This polymer material is partially resorbable. That supports not only the growth of bone cells but also serves as a protective layer. It reduces friction between organic tissues and a metal implant and can be a solution to the problem of the aseptic instability of metal implants. The material can also be used to repair damaged bones and cartilage tissues, especially in cases where the application and curing procedure is performed using laparoscopic methods. In this work, the authors propose a simple and quite cheap method for obtaining material based on photopolymerizable acrylates and natural gelatin with nanoparticles of HA, zinc oxide, and silicon oxide. The method allows one to obtain a composite material with different nanoparticles in a polymer matrix which retain the requisite properties needed such as active-sized HA, antibacterial ZnO, and structure-forming and stability-improving SiO2 nanoparticles.
AB - The development and analysis of the properties of a new material based on UV-curable acrylate monomers with silicon-containing hydroxyapatite and zinc oxide nanoparticles as an antibacterial component and gelatin was carried out. Using this material in orthopedics and dentistry is very convenient because it covers any surface geometry of metal implants and hardens under ultraviolet light. In this work, sorption properties, changes in porosity, and mechanical properties of the material were investigated. The conditions for obtaining hydroxyapatite (HA) nanoparticles and the presence of silicon oxide nanoparticles and organic for the shell in an aqueous medium were studied for the pH of the medium, the sequence of administration and concentration of the material components, as well as antibacterial properties. This polymer material is partially resorbable. That supports not only the growth of bone cells but also serves as a protective layer. It reduces friction between organic tissues and a metal implant and can be a solution to the problem of the aseptic instability of metal implants. The material can also be used to repair damaged bones and cartilage tissues, especially in cases where the application and curing procedure is performed using laparoscopic methods. In this work, the authors propose a simple and quite cheap method for obtaining material based on photopolymerizable acrylates and natural gelatin with nanoparticles of HA, zinc oxide, and silicon oxide. The method allows one to obtain a composite material with different nanoparticles in a polymer matrix which retain the requisite properties needed such as active-sized HA, antibacterial ZnO, and structure-forming and stability-improving SiO2 nanoparticles.
KW - composite
KW - dentistry
KW - hydroxyapatite
KW - nanoparticles
KW - orthopedics
KW - polymer materials
KW - regenerative medicine
UR - https://www.mendeley.com/catalogue/9544c504-f939-39ad-b1a5-ad0ede9c90ac/
U2 - 10.3390/jcs9020065
DO - 10.3390/jcs9020065
M3 - Article
VL - 9
JO - Journal of Composites Science
JF - Journal of Composites Science
SN - 2504-477X
IS - 2
M1 - 65
ER -
ID: 142761497