@article{c4dab3419a0c4a7494b719c52a655e7b,
title = "An isoxazole strategy for the synthesis of alkyl 5-amino-4-cyano-1H-pyrrole-2-carboxylates - versatile building blocks for assembling pyrrolo-fused heterocycles",
abstract = "A full atom-economical domino method has been developed for the preparation of alkyl 5-amino-4-cyano-1H-pyrrole-2-carboxylates by transannulation of 5-alkoxyisoxazoles with malononitrile under Fe(ii) catalysis. Alkyl 5-amino-4-cyano-1H-pyrrole-2-carboxylates are excellent building blocks for various annulation reactions, leading to new derivatives of 1H-pyrrolo[1,2-a]imidazole and pyrrolo[2,3-d]pyrimidine. The DFT calculations of mechanistic details of alkyl 5-amino-4-cyano-1H-pyrrole-2-carboxylate formation are presented.",
author = "Agafonova, {Anastasiya V.} and Funt, {Liya D.} and Novikov, {Mikhail S.} and Khlebnikov, {Alexander F.}",
note = "Funding Information: We gratefully acknowledge the financial support from the Russian Science Foundation (Grant no. 19-13-00039). This research used resources of the Magnetic Resonance Research Centre, Chemical Analysis, Materials Research Centre, Centre for X-ray Diffraction Studies, and the Computer Centre of the Science Park of Saint Petersburg State University. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2021. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = mar,
day = "7",
doi = "10.1039/d1ob00053e",
language = "English",
volume = "19",
pages = "1976--1984",
journal = "Organic and Biomolecular Chemistry",
issn = "1477-0520",
publisher = "Royal Society of Chemistry",
number = "9",
}