An efficient synthesis of substituted spiro[isoxazolopyrroloisoquinolines] via diastereoselective N-acyliminium ion cyclization

Maria S. Ledovskaya, Alexander V. Stepakov, Alexander P. Molchanov, Rafael R. Kostikov

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

© 2015 Elsevier Ltd.A simple and efficient strategy is reported for the synthesis of spiro-fused pyrrolo[2,1-a]isoquinoline ring systems. The spiro[isoxazolopyrroloisoquinolines] are readily prepared via diastereoselective N-acyliminium ion cyclization of 6-hydroxy-7-(2-arylethyl)-1-oxa-2,7-diazaspiro[4.4]non-2-en-8-ones derived from the corresponding spirocyclic dihydroisoxazoles.
Original languageEnglish
Pages (from-to)7562-7566
JournalTetrahedron
Volume71
Issue number40
DOIs
StatePublished - 2015

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