Amphiphilic star-shaped brushes based on block copolymers-molecular micelles for the delivery of drugs: Hydrodynamic studies

G.M. Pavlov, O.V. Okatova, A.S. Gubarev, K. Knop, U.S. Schubert

Research output

2 Citations (Scopus)

Abstract

Brushshaped molecular stars of poly(εcaprolactone)blockpoly(oligo(ethylene glycol) meth acrylate) are synthesized, their hydrodynamic properties are studied, and their molecular characteristics are measured. For dilute solutions of the copolymers in acetone, viscous flow, velocity sedimentation, and trans lational diffusion of the macromolecules are investigated. The molecular masses of the copolymers are deter mined via the Svedberg relation. Correlations between hydrodynamic characteristics and molecular masses in the range 46 <M × 10–3 g mol–1 <266 are obtained. The existence of scaling relationships makes it possible to infer that the resulting copolymers belong to a hydrodynamically similar series of macromolecules: hydro dynamic homologs. It is shown that copolymer macromolecules have a denser organization in space than that of both linear macromolecules and conventional molecular stars. A model of macromolecules of poly(ε caprolactone)blockpoly(oligo(ethylene glycol) methacrylate) copolymers that is
Original languageEnglish
Pages (from-to)115-122
JournalPolymer Science - Series A
Volume57
Issue number2
DOIs
Publication statusPublished - 2015

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