Allelic variants of hereditary prions: The bimodularity principle

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2 Citations (Scopus)

Abstract

Modern biology requires modern genetic concepts equally valid for all discovered mechanisms of inheritance, either “canonical” (mediated by DNA sequences) or epigenetic. Applying basic genetic terms such as “gene” and “allele” to protein hereditary factors is one of the necessary steps toward these concepts. The basic idea that different variants of the same prion protein can be considered as alleles has been previously proposed by Chernoff and Tuite. In this paper, the notion of prion allele is further developed. We propose the idea that any prion allele is a bimodular hereditary system that depends on a certain DNA sequence (DNA determinant) and a certain epigenetic mark (epigenetic determinant). Alteration of any of these 2 determinants may lead to establishment of a new prion allele. The bimodularity principle is valid not only for hereditary prions; it seems to be universal for any epigenetic hereditary factor.
Original languageEnglish
Pages (from-to)4-24
JournalPrion
Volume11
Issue number1
Publication statusPublished - 2017

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Prions
Epigenomics
Alleles
DNA sequences
Genetic Phenomena
Genes
DNA
Proteins

Cite this

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title = "Allelic variants of hereditary prions: The bimodularity principle",
abstract = "Modern biology requires modern genetic concepts equally valid for all discovered mechanisms of inheritance, either “canonical” (mediated by DNA sequences) or epigenetic. Applying basic genetic terms such as “gene” and “allele” to protein hereditary factors is one of the necessary steps toward these concepts. The basic idea that different variants of the same prion protein can be considered as alleles has been previously proposed by Chernoff and Tuite. In this paper, the notion of prion allele is further developed. We propose the idea that any prion allele is a bimodular hereditary system that depends on a certain DNA sequence (DNA determinant) and a certain epigenetic mark (epigenetic determinant). Alteration of any of these 2 determinants may lead to establishment of a new prion allele. The bimodularity principle is valid not only for hereditary prions; it seems to be universal for any epigenetic hereditary factor.",
keywords = "amyloid, conformational template, epigenetic inheritance, prion, prion strain, prion variant, the bimodularity principle",
author = "Tikhodeyev, {Oleg N.} and Tarasov, {Oleg V.} and Bondarev, {Stanislav A.}",
year = "2017",
language = "English",
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journal = "Prion",
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TY - JOUR

T1 - Allelic variants of hereditary prions: The bimodularity principle

AU - Tikhodeyev, Oleg N.

AU - Tarasov, Oleg V.

AU - Bondarev, Stanislav A.

PY - 2017

Y1 - 2017

N2 - Modern biology requires modern genetic concepts equally valid for all discovered mechanisms of inheritance, either “canonical” (mediated by DNA sequences) or epigenetic. Applying basic genetic terms such as “gene” and “allele” to protein hereditary factors is one of the necessary steps toward these concepts. The basic idea that different variants of the same prion protein can be considered as alleles has been previously proposed by Chernoff and Tuite. In this paper, the notion of prion allele is further developed. We propose the idea that any prion allele is a bimodular hereditary system that depends on a certain DNA sequence (DNA determinant) and a certain epigenetic mark (epigenetic determinant). Alteration of any of these 2 determinants may lead to establishment of a new prion allele. The bimodularity principle is valid not only for hereditary prions; it seems to be universal for any epigenetic hereditary factor.

AB - Modern biology requires modern genetic concepts equally valid for all discovered mechanisms of inheritance, either “canonical” (mediated by DNA sequences) or epigenetic. Applying basic genetic terms such as “gene” and “allele” to protein hereditary factors is one of the necessary steps toward these concepts. The basic idea that different variants of the same prion protein can be considered as alleles has been previously proposed by Chernoff and Tuite. In this paper, the notion of prion allele is further developed. We propose the idea that any prion allele is a bimodular hereditary system that depends on a certain DNA sequence (DNA determinant) and a certain epigenetic mark (epigenetic determinant). Alteration of any of these 2 determinants may lead to establishment of a new prion allele. The bimodularity principle is valid not only for hereditary prions; it seems to be universal for any epigenetic hereditary factor.

KW - amyloid

KW - conformational template

KW - epigenetic inheritance

KW - prion

KW - prion strain

KW - prion variant

KW - the bimodularity principle

M3 - Review article

VL - 11

SP - 4

EP - 24

JO - Prion

JF - Prion

SN - 1933-6896

IS - 1

ER -