Advanced palladium free approach to the synthesis of substituted alkene oxindoles: Via aluminum-promoted Knoevenagel reaction

Daria S. Novikova, Tatyana A. Grigoreva, Andrey A. Zolotarev, Alexander V. Garabadzhiu, Vyacheslav G. Tribulovich

Research output

Abstract

A synthetic route for the synthesis of C24, as well as for the design of focused libraries of direct AMPK activators was developed based on a convergent strategy. The proposed scheme corresponds to the current trends in C-H bond functionalization. The use of aluminum isopropoxide for the Knoevenagel condensation of oxindole with benzophenones is a noticeable point of this work.

Original languageEnglish
Pages (from-to)34543-34551
Number of pages9
JournalRSC Advances
Volume8
Issue number60
DOIs
Publication statusPublished - 1 Jan 2018

Fingerprint

Benzophenones
AMP-Activated Protein Kinases
Palladium
Alkenes
Aluminum
Olefins
Condensation
oxindole

Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Novikova, Daria S. ; Grigoreva, Tatyana A. ; Zolotarev, Andrey A. ; Garabadzhiu, Alexander V. ; Tribulovich, Vyacheslav G. / Advanced palladium free approach to the synthesis of substituted alkene oxindoles : Via aluminum-promoted Knoevenagel reaction. In: RSC Advances. 2018 ; Vol. 8, No. 60. pp. 34543-34551.
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Advanced palladium free approach to the synthesis of substituted alkene oxindoles : Via aluminum-promoted Knoevenagel reaction. / Novikova, Daria S.; Grigoreva, Tatyana A.; Zolotarev, Andrey A.; Garabadzhiu, Alexander V.; Tribulovich, Vyacheslav G.

In: RSC Advances, Vol. 8, No. 60, 01.01.2018, p. 34543-34551.

Research output

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AU - Garabadzhiu, Alexander V.

AU - Tribulovich, Vyacheslav G.

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