Advanced palladium free approach to the synthesis of substituted alkene oxindoles: Via aluminum-promoted Knoevenagel reaction

Daria S. Novikova, Tatyana A. Grigoreva, Andrey A. Zolotarev, Alexander V. Garabadzhiu, Vyacheslav G. Tribulovich

Research output

3 Citations (Scopus)

Abstract

A synthetic route for the synthesis of C24, as well as for the design of focused libraries of direct AMPK activators was developed based on a convergent strategy. The proposed scheme corresponds to the current trends in C-H bond functionalization. The use of aluminum isopropoxide for the Knoevenagel condensation of oxindole with benzophenones is a noticeable point of this work.

Original languageEnglish
Pages (from-to)34543-34551
Number of pages9
JournalRSC Advances
Volume8
Issue number60
DOIs
Publication statusPublished - 1 Jan 2018

Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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