Acute behavioral effects of deliriant hallucinogens atropine and scopolamine in adult zebrafish

Andrey D. Volgin, Oleg A. Yakovlev, Konstantin A. Demin, Polina A. Alekseeva, Allan V. Kalueff

Research output

4 Citations (Scopus)

Abstract

Atropine and scopolamine are classical muscarinic cholinergic antagonists that exert multiple CNS effects. Belonging to a group of deliriant hallucinogens, these drugs induce delirium-like hallucinations, hyperactivity, altered affective states and amnesia. However, as deliriants remain the least studied group of hallucinogens, their complex and poorly understood profiles necessitate further clinical and preclinical studies. The zebrafish (Danio rerio) is rapidly emerging as a powerful model organism for translational neuropsychopharmacology research. Here, we characterize acute behavioral effects of atropine (60, 90 and 120 mg/L) and scopolamine (60, 120, 180 and 240 mg/L) in adult zebrafish subjected to the novel tank (NTT), light-dark (LDT) and shoaling tests. Overall, atropine at 90 mg/L only mildly increased the NTT locomotor activity, scopolamine at 120 mg/L produced anxiogenic-like NTT effects without affecting other behaviors, and both drugs similarly disrupted zebrafish group behavior in the shoaling test. Collectively, this supports complex and partially overlapping deliriant-like effects of acute atropine and scopolamine in zebrafish. The behavioral sensitivity to these drugs suggests zebrafish as potential screens for cholinergic deliriant psychotropic agents, also necessitating further cross-species in-vivo experimental studies.

Original languageEnglish
Pages (from-to)274-280
Number of pages7
JournalBehavioural Brain Research
Volume359
DOIs
Publication statusPublished - 1 Feb 2019

Fingerprint

Hallucinogens
Scopolamine Hydrobromide
Zebrafish
Atropine
Pharmaceutical Preparations
Muscarinic Antagonists
Translational Medical Research
Amnesia
Delirium
Hallucinations
Locomotion
Cholinergic Agents
Light

Scopus subject areas

  • Behavioral Neuroscience

Cite this

@article{d6ad0dc2f4684ebabc0ace2bf92775bf,
title = "Acute behavioral effects of deliriant hallucinogens atropine and scopolamine in adult zebrafish",
abstract = "Atropine and scopolamine are classical muscarinic cholinergic antagonists that exert multiple CNS effects. Belonging to a group of deliriant hallucinogens, these drugs induce delirium-like hallucinations, hyperactivity, altered affective states and amnesia. However, as deliriants remain the least studied group of hallucinogens, their complex and poorly understood profiles necessitate further clinical and preclinical studies. The zebrafish (Danio rerio) is rapidly emerging as a powerful model organism for translational neuropsychopharmacology research. Here, we characterize acute behavioral effects of atropine (60, 90 and 120 mg/L) and scopolamine (60, 120, 180 and 240 mg/L) in adult zebrafish subjected to the novel tank (NTT), light-dark (LDT) and shoaling tests. Overall, atropine at 90 mg/L only mildly increased the NTT locomotor activity, scopolamine at 120 mg/L produced anxiogenic-like NTT effects without affecting other behaviors, and both drugs similarly disrupted zebrafish group behavior in the shoaling test. Collectively, this supports complex and partially overlapping deliriant-like effects of acute atropine and scopolamine in zebrafish. The behavioral sensitivity to these drugs suggests zebrafish as potential screens for cholinergic deliriant psychotropic agents, also necessitating further cross-species in-vivo experimental studies.",
keywords = "Anxiety, Atropine, Deliriant hallucinogens, Locomotion, Scopolamine, Zebrafish",
author = "Volgin, {Andrey D.} and Yakovlev, {Oleg A.} and Demin, {Konstantin A.} and Alekseeva, {Polina A.} and Kalueff, {Allan V.}",
year = "2019",
month = "2",
day = "1",
doi = "10.1016/j.bbr.2018.10.033",
language = "English",
volume = "359",
pages = "274--280",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",

}

Acute behavioral effects of deliriant hallucinogens atropine and scopolamine in adult zebrafish. / Volgin, Andrey D.; Yakovlev, Oleg A.; Demin, Konstantin A.; Alekseeva, Polina A.; Kalueff, Allan V.

In: Behavioural Brain Research, Vol. 359, 01.02.2019, p. 274-280.

Research output

TY - JOUR

T1 - Acute behavioral effects of deliriant hallucinogens atropine and scopolamine in adult zebrafish

AU - Volgin, Andrey D.

AU - Yakovlev, Oleg A.

AU - Demin, Konstantin A.

AU - Alekseeva, Polina A.

AU - Kalueff, Allan V.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Atropine and scopolamine are classical muscarinic cholinergic antagonists that exert multiple CNS effects. Belonging to a group of deliriant hallucinogens, these drugs induce delirium-like hallucinations, hyperactivity, altered affective states and amnesia. However, as deliriants remain the least studied group of hallucinogens, their complex and poorly understood profiles necessitate further clinical and preclinical studies. The zebrafish (Danio rerio) is rapidly emerging as a powerful model organism for translational neuropsychopharmacology research. Here, we characterize acute behavioral effects of atropine (60, 90 and 120 mg/L) and scopolamine (60, 120, 180 and 240 mg/L) in adult zebrafish subjected to the novel tank (NTT), light-dark (LDT) and shoaling tests. Overall, atropine at 90 mg/L only mildly increased the NTT locomotor activity, scopolamine at 120 mg/L produced anxiogenic-like NTT effects without affecting other behaviors, and both drugs similarly disrupted zebrafish group behavior in the shoaling test. Collectively, this supports complex and partially overlapping deliriant-like effects of acute atropine and scopolamine in zebrafish. The behavioral sensitivity to these drugs suggests zebrafish as potential screens for cholinergic deliriant psychotropic agents, also necessitating further cross-species in-vivo experimental studies.

AB - Atropine and scopolamine are classical muscarinic cholinergic antagonists that exert multiple CNS effects. Belonging to a group of deliriant hallucinogens, these drugs induce delirium-like hallucinations, hyperactivity, altered affective states and amnesia. However, as deliriants remain the least studied group of hallucinogens, their complex and poorly understood profiles necessitate further clinical and preclinical studies. The zebrafish (Danio rerio) is rapidly emerging as a powerful model organism for translational neuropsychopharmacology research. Here, we characterize acute behavioral effects of atropine (60, 90 and 120 mg/L) and scopolamine (60, 120, 180 and 240 mg/L) in adult zebrafish subjected to the novel tank (NTT), light-dark (LDT) and shoaling tests. Overall, atropine at 90 mg/L only mildly increased the NTT locomotor activity, scopolamine at 120 mg/L produced anxiogenic-like NTT effects without affecting other behaviors, and both drugs similarly disrupted zebrafish group behavior in the shoaling test. Collectively, this supports complex and partially overlapping deliriant-like effects of acute atropine and scopolamine in zebrafish. The behavioral sensitivity to these drugs suggests zebrafish as potential screens for cholinergic deliriant psychotropic agents, also necessitating further cross-species in-vivo experimental studies.

KW - Anxiety

KW - Atropine

KW - Deliriant hallucinogens

KW - Locomotion

KW - Scopolamine

KW - Zebrafish

UR - http://www.scopus.com/inward/record.url?scp=85056653791&partnerID=8YFLogxK

U2 - 10.1016/j.bbr.2018.10.033

DO - 10.1016/j.bbr.2018.10.033

M3 - Article

C2 - 30366034

AN - SCOPUS:85056653791

VL - 359

SP - 274

EP - 280

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

ER -