Abnormal Membrane Localization of α2 Isoform of Na,K-ATPase in m. soleus of Dysferlin-Deficient Mice

V.V. Kravtsova, E.V. Bouzinova, V.V. Matchkov , N.A. Timonina, G.F. Zakyrjanova, A.L. Zefirov, I.I. Krivoi

Research output

3 Citations (Scopus)

Abstract

Dysferlin protein plays a key role in the multimolecular complex responsible for the maintenance of sarcolemma integrity and skeletal muscle cell functioning. We studied the membrane distribution of nicotinic acetylcholine receptors and α2 isoform of Na,K-ATPase in motor endplates of m. soleus in dysferlin-deficient Bla/J mice (a dysferlinopathy model). Endplates of Bla/J mice were characterized by increased area (without changes in fragmentation degree) and reduced density of the membrane distribution of nicotinic acetylcholine receptors in comparison with the corresponding parameters in control С57Bl/6 mice. The density of the membrane distribution of α2 isoform of Na,K-ATPase was also reduced, but the level of the corresponding mRNA remained unchanged. It can be hypothesized that abnormal membrane localization of α2 isoform of Na,K-ATPase results from adaptive skeletal muscle remodeling under conditions of chronic motor dysfunction.

Original languageEnglish
Pages (from-to)593-597
JournalBulletin of Experimental Biology and Medicine
Volume166
Issue number5
Early online date23 Mar 2019
DOIs
Publication statusPublished - 2019

Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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