A three-component, Zn(OTf)2-mediated entry into trisubstituted 2-aminoimidazoles

Alexei Lukin, Anna Bakholdina, Anna Kryukova, Alexander Sapegin, Mikhail Krasavin

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    3 Citations (Scopus)


    A three-component reaction involving in situ generation of propargylureas and subsequent Zn(OTf)2-mediated cyclocondensation with a primary amine yielded trisubstituted 2-aminoimidazoles. These findings are in contrast to the previously reported basepromoted unimolecular cyclization of propargylureas (leading to 2-imidazolones) and extend the range of Lewis acid-catalyzed azole syntheses based on N-carbonyl propargylamines.

    Original languageEnglish
    Pages (from-to)1061-1064
    Number of pages4
    JournalBeilstein Journal of Organic Chemistry
    Publication statusPublished - 1 Jan 2019

    Scopus subject areas

    • Organic Chemistry

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