A Novel Approach to Substituted α-Carbamoyl Phosphonates: Useful Reagents for the Horner-Wadsworth-Emmons Olefination

Research output

1 Citation (Scopus)

Abstract

α-Carbamoyl phosphonates are useful reagents for the Horner-Wadsworth-Emmons olefination of aldehydes en route to medicinally relevant polysubstituted acrylamides. A new synthetic approach to these reagents has been developed. The methodology relies on the microwave-promoted Wolff rearrangement of α-acyl-α-diazophosphonates with trapping of the ketene intermediate in situ with various amines.

Original languageEnglish
JournalSynlett
DOIs
Publication statusE-pub ahead of print - 20 Jun 2020

Scopus subject areas

  • Organic Chemistry

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