A novel approach to biologically relevant oxazolo[5,4-d]pyrimidine-5,7-diones via readily available diazobarbituric acid derivatives

Research output


An alternative route from 1,3-disubstituted barbituric acids to biologically relevant oxazolo[5,4-d]pyrimidine-5,7-diones was developed that features sulfonyl-azide-free (SAFE) diazo transfer and Rh2(esp)2-catalyzed cycloaddition of the resulting 5-diazobarbituric acids with aliphatic and aromatic nitriles. Besides being shorter compared to the previously described approaches, the method allows introduction of alkyl substituents at the 1,3-oxazole ring of the fused heterocyclic system.

Original languageEnglish
Article number151120
JournalTetrahedron Letters
Issue number44
Early online date6 Sep 2019
Publication statusPublished - 31 Oct 2019


Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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