Research output: Contribution to journal › Article › peer-review
A novel one-step method for the preparation of 5H-pyrazino[2,3-b]indoles with different substitution patterns in all rings of the tricyclic system via the Rh2(OAc)4-catalyzed reaction of 2H-azirines with 3-diazoindolin-2-imines is reported. Alkyl 5H-pyrazino[2,3-b]indole-3-carboxylates were also prepared by a one-pot procedure from synthetic equivalents of alkyl 2H-azirine-2-carboxylates, 5-alkoxyisoxazoles. The reactions provide the first examples of the use of Rh(ii) catalysis for intermolecular annulations with 2H-azirines and isoxazoles.
Original language | English |
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Pages (from-to) | 38-42 |
Number of pages | 5 |
Journal | Organic and Biomolecular Chemistry |
Volume | 16 |
Issue number | 1 |
DOIs | |
State | Published - 7 Jan 2018 |
ID: 13392451