A novel aminotriazole-based NHC complex for the design of gold(I) anti-cancer agents: synthesis and biological evaluation

T.V. Serebryanskaya, A.A. Zolotarev, I. Ott

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

A novel gold(I) complex based on an aminotriazole N-heterocylic carbene ligand represents a promising scaffold for the design of anticancer bioorganometallics. The complex triggered cytotoxic effects in HT-29 and MDA-MB-231 cancer cells, inhibited the activity of the enzyme thioredoxin reductase and showed an effective and fast cellular accumulation.
Original languageEnglish
Pages (from-to)1186-1189
JournalMedChemComm
Volume6
Issue number6
DOIs
StatePublished - 2015

Keywords

  • Gold(I) NHC complex
  • triazolium salt
  • anticancer activity
  • TrX inhibition
  • cellular uptake

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