A novel aminotriazole-based NHC complex for the design of gold(I) anti-cancer agents: synthesis and biological evaluation

T.V. Serebryanskaya; A.A. Zolotarev; I. Ott

doi:10.1039/c5md00185d

A novel aminotriazole-based NHC complex for the design of gold(I) anti-cancer agents: synthesis and biological evaluation

T.V. Serebryanskaya, A.A. Zolotarev, I. Ott

Кафедра кристаллографии

Research output

24 Citations (Scopus)

Abstract

A novel gold(I) complex based on an aminotriazole N-heterocylic carbene ligand represents a promising scaffold for the design of anticancer bioorganometallics. The complex triggered cytotoxic effects in HT-29 and MDA-MB-231 cancer cells, inhibited the activity of the enzyme thioredoxin reductase and showed an effective and fast cellular accumulation.

Original language	English
Pages (from-to)	1186-1189
Journal	MedChemComm
Volume	6
Issue number	6
DOIs	https://doi.org/10.1039/c5md00185d
Publication status	Published - 2015

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http://pubs.rsc.org/en/Content/ArticleLanding/2015/MD/c5md00185d#!divAbstract

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title = "A novel aminotriazole-based NHC complex for the design of gold(I) anti-cancer agents: synthesis and biological evaluation",

abstract = "A novel gold(I) complex based on an aminotriazole N-heterocylic carbene ligand represents a promising scaffold for the design of anticancer bioorganometallics. The complex triggered cytotoxic effects in HT-29 and MDA-MB-231 cancer cells, inhibited the activity of the enzyme thioredoxin reductase and showed an effective and fast cellular accumulation.",

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AB - A novel gold(I) complex based on an aminotriazole N-heterocylic carbene ligand represents a promising scaffold for the design of anticancer bioorganometallics. The complex triggered cytotoxic effects in HT-29 and MDA-MB-231 cancer cells, inhibited the activity of the enzyme thioredoxin reductase and showed an effective and fast cellular accumulation.

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KW - anticancer activity

KW - TrX inhibition

KW - cellular uptake

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