Abstract
A novel gold(I) complex based on an aminotriazole N-heterocylic carbene ligand represents a promising scaffold for the design of anticancer bioorganometallics. The complex triggered cytotoxic effects in HT-29 and MDA-MB-231 cancer cells, inhibited the activity of the enzyme thioredoxin reductase and showed an effective and fast cellular accumulation.
| Original language | English |
|---|---|
| Pages (from-to) | 1186-1189 |
| Journal | MedChemComm |
| Volume | 6 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2015 |
Fingerprint
Cite this
Serebryanskaya, T. V., Zolotarev, A. A., & Ott, I. (2015). A novel aminotriazole-based NHC complex for the design of gold(I) anti-cancer agents: synthesis and biological evaluation. MedChemComm, 6(6), 1186-1189. https://doi.org/10.1039/c5md00185d