A novel aminotriazole-based NHC complex for the design of gold(I) anti-cancer agents: synthesis and biological evaluation

T.V. Serebryanskaya; A.A. Zolotarev; I. Ott

doi:10.1039/c5md00185d

A novel aminotriazole-based NHC complex for the design of gold(I) anti-cancer agents: synthesis and biological evaluation

T.V. Serebryanskaya, A.A. Zolotarev, I. Ott

Department of Crystallography

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26 Scopus citations

Abstract

A novel gold(I) complex based on an aminotriazole N-heterocylic carbene ligand represents a promising scaffold for the design of anticancer bioorganometallics. The complex triggered cytotoxic effects in HT-29 and MDA-MB-231 cancer cells, inhibited the activity of the enzyme thioredoxin reductase and showed an effective and fast cellular accumulation.

Original language	English
Pages (from-to)	1186-1189
Journal	MedChemComm
Volume	6
Issue number	6
DOIs	https://doi.org/10.1039/c5md00185d
State	Published - 2015

Keywords

Gold(I) NHC complex
triazolium salt
anticancer activity
TrX inhibition
cellular uptake

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10.1039/c5md00185d

http://pubs.rsc.org/en/Content/ArticleLanding/2015/MD/c5md00185d#!divAbstract

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title = "A novel aminotriazole-based NHC complex for the design of gold(I) anti-cancer agents: synthesis and biological evaluation",

abstract = "A novel gold(I) complex based on an aminotriazole N-heterocylic carbene ligand represents a promising scaffold for the design of anticancer bioorganometallics. The complex triggered cytotoxic effects in HT-29 and MDA-MB-231 cancer cells, inhibited the activity of the enzyme thioredoxin reductase and showed an effective and fast cellular accumulation.",

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AU - Zolotarev, A.A.

AU - Ott, I.

PY - 2015

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AB - A novel gold(I) complex based on an aminotriazole N-heterocylic carbene ligand represents a promising scaffold for the design of anticancer bioorganometallics. The complex triggered cytotoxic effects in HT-29 and MDA-MB-231 cancer cells, inhibited the activity of the enzyme thioredoxin reductase and showed an effective and fast cellular accumulation.

KW - Gold(I) NHC complex

KW - triazolium salt

KW - anticancer activity

KW - TrX inhibition

KW - cellular uptake

U2 - 10.1039/c5md00185d

DO - 10.1039/c5md00185d

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JF - MedChemComm

SN - 2040-2503

IS - 6

ER -

A novel aminotriazole-based NHC complex for the design of gold(I) anti-cancer agents: synthesis and biological evaluation

Abstract

Keywords

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