A novel aminotriazole-based NHC complex for the design of gold(I) anti-cancer agents: synthesis and biological evaluation

T.V. Serebryanskaya, A.A. Zolotarev, I. Ott

Research output

21 Citations (Scopus)

Abstract

A novel gold(I) complex based on an aminotriazole N-heterocylic carbene ligand represents a promising scaffold for the design of anticancer bioorganometallics. The complex triggered cytotoxic effects in HT-29 and MDA-MB-231 cancer cells, inhibited the activity of the enzyme thioredoxin reductase and showed an effective and fast cellular accumulation.
Original languageEnglish
Pages (from-to)1186-1189
JournalMedChemComm
Volume6
Issue number6
DOIs
Publication statusPublished - 2015

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