A Low-Cost, Simple Method for Isotopic Analysis of Enriched Boron Pharmaceutical Substances by Capillary Zone Electrophoresis with Indirect UV Detection

Yulia Malinina, Nina Yakimova, Leonid Moskvin, Kirill Tkach, Mikhail Kamentsev, Irina Kuchumova

Research output: Contribution to journalArticlepeer-review

Abstract

A novel, cheap and simple method for the determination of 10B and 11B mole fractions in 10B enriched boron compounds by capillary zone electrophoresis with indirect UV detection was developed. The background electrolyte contained 35 mM phenylalanine adjusted to pH of 8.8 with putrescine. The running conditions were + 25 kV at 34° C. Indirect photometric detection was performed at 210 nm. The analysis time was less than 17 min. The interday RSD of migration times and peak areas were less than 0.9% and 2.3%, respectively (n = 18). Linearity was demonstrated in the range 0.3–15 mM for both isotopes. Analysis of boron compounds with mole fraction of 10B ranging from 19.8 (natural abundance) up to 90.0% was successfully demonstrated.
Original languageEnglish
Pages (from-to)393-398
JournalChromatographia
Volume84
StatePublished - 2021

Scopus subject areas

  • Chemistry(all)

Keywords

  • Capillary electrophoresis
  • Capillary zone electrophoresis
  • Isotopic separation
  • Boron neutron capture
  • Boron isotope

Fingerprint

Dive into the research topics of 'A Low-Cost, Simple Method for Isotopic Analysis of Enriched Boron Pharmaceutical Substances by Capillary Zone Electrophoresis with Indirect UV Detection'. Together they form a unique fingerprint.

Cite this