A chemiluminescence method for screening of fluoroquinolones in milk samples based on a multi-pumping flow system

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Abstract

An automated and miniaturized chemiluminescence method for screening of fluoroquinolones in milk samples was proposed. The method was based on magnetic dispersive micro-solid phase extraction of analytes followed by the chemiluminescence determination of the total fluoroquinolones content using a multi-pumping flow system. In the developed method, Zr-Fe-C magnetic nanoparticles were used as an efficient sorbent for separation of fluoroquinolones from sample matrix. The chemiluminescence intensity obtained for Ce4+-SO32--Tb3+ chemiluminescence system was greatly increased in the presence of the analytes. Under the optimal conditions, the detector response for fluoroquinolones was linear in the concentration ranges from 5 center dot 10(-9) to 1 center dot 10(-6) mol L-1 with respect to fleroxacin. The limit of detection, calculated from a blank test based on 3s, was 2 center dot 10(-9) mol L-1 with respect to fleroxacin. The presented method demonstrated to be a good tool for available and cost-effective point-of-need screening fluoroquinolones in milk samples.

LanguageEnglish
Pages10-16
Number of pages7
JournalFood Chemistry
Volume270
DOIs
StatePublished - 1 Jan 2019

Keywords

  • Ammonium cerium (IV) nitrate (PubChem CID: 9869224)
  • Ammonium hydroxide (PubChem CID: 14923)
  • Chemiluminescence
  • Direct-injection detector
  • Fleroxacin (PubChem CID: 3357)
  • Fluoroquinolones
  • Lomefloxacin (PubChem CID: 3948)
  • Magnetic dispersive micro-solid phase extraction
  • Methanol (PubChem CID: 887)
  • Milk
  • Multi-pumping flow system
  • Norfloxacin (PubChem CID: 4539)
  • Ofloxacin (PubChem CID: 4583)
  • Screening
  • Sodium hydroxide (PubChem CID: 14798)
  • Sodium sulfite (PubChem CID: 24437)
  • Terbium chloride hexahydrate (PubChem CID: 203091)
  • HPLC-FLD DETERMINATION
  • SULFONAMIDE
  • OFLOXACIN
  • SENSITIZED CHEMILUMINESCENCE
  • SOLID-PHASE EXTRACTION
  • ASSAY
  • MEAT
  • LIQUID-CHROMATOGRAPHY
  • RESIDUES

Scopus subject areas

  • Analytical Chemistry
  • Food Science

Cite this

@article{32aec57fcce7426ba8b8ce8dd72c6833,
title = "A chemiluminescence method for screening of fluoroquinolones in milk samples based on a multi-pumping flow system",
abstract = "An automated and miniaturized chemiluminescence method for screening of fluoroquinolones in milk samples was proposed. The method was based on magnetic dispersive micro-solid phase extraction of analytes followed by the chemiluminescence determination of the total fluoroquinolones content using a multi-pumping flow system. In the developed method, Zr-Fe-C magnetic nanoparticles were used as an efficient sorbent for separation of fluoroquinolones from sample matrix. The chemiluminescence intensity obtained for Ce4+-SO32--Tb3+ chemiluminescence system was greatly increased in the presence of the analytes. Under the optimal conditions, the detector response for fluoroquinolones was linear in the concentration ranges from 5 center dot 10(-9) to 1 center dot 10(-6) mol L-1 with respect to fleroxacin. The limit of detection, calculated from a blank test based on 3s, was 2 center dot 10(-9) mol L-1 with respect to fleroxacin. The presented method demonstrated to be a good tool for available and cost-effective point-of-need screening fluoroquinolones in milk samples.",
keywords = "Ammonium cerium (IV) nitrate (PubChem CID: 9869224), Ammonium hydroxide (PubChem CID: 14923), Chemiluminescence, Direct-injection detector, Fleroxacin (PubChem CID: 3357), Fluoroquinolones, Lomefloxacin (PubChem CID: 3948), Magnetic dispersive micro-solid phase extraction, Methanol (PubChem CID: 887), Milk, Multi-pumping flow system, Norfloxacin (PubChem CID: 4539), Ofloxacin (PubChem CID: 4583), Screening, Sodium hydroxide (PubChem CID: 14798), Sodium sulfite (PubChem CID: 24437), Terbium chloride hexahydrate (PubChem CID: 203091), HPLC-FLD DETERMINATION, SULFONAMIDE, OFLOXACIN, SENSITIZED CHEMILUMINESCENCE, SOLID-PHASE EXTRACTION, ASSAY, MEAT, LIQUID-CHROMATOGRAPHY, RESIDUES",
author = "Кристина Вах and Булатов, {Андрей Васильевич} and Почивалов, {Алексей Сергеевич} and Постнов, {Виктор Николаевич} and S. Koronkiewicz and S. Kalinowski",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.foodchem.2018.07.073",
language = "English",
volume = "270",
pages = "10--16",
journal = "Food Chemistry",
issn = "0308-8146",
publisher = "Elsevier",

}

TY - JOUR

T1 - A chemiluminescence method for screening of fluoroquinolones in milk samples based on a multi-pumping flow system

AU - Вах, Кристина

AU - Булатов, Андрей Васильевич

AU - Почивалов, Алексей Сергеевич

AU - Постнов, Виктор Николаевич

AU - Koronkiewicz, S.

AU - Kalinowski, S.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - An automated and miniaturized chemiluminescence method for screening of fluoroquinolones in milk samples was proposed. The method was based on magnetic dispersive micro-solid phase extraction of analytes followed by the chemiluminescence determination of the total fluoroquinolones content using a multi-pumping flow system. In the developed method, Zr-Fe-C magnetic nanoparticles were used as an efficient sorbent for separation of fluoroquinolones from sample matrix. The chemiluminescence intensity obtained for Ce4+-SO32--Tb3+ chemiluminescence system was greatly increased in the presence of the analytes. Under the optimal conditions, the detector response for fluoroquinolones was linear in the concentration ranges from 5 center dot 10(-9) to 1 center dot 10(-6) mol L-1 with respect to fleroxacin. The limit of detection, calculated from a blank test based on 3s, was 2 center dot 10(-9) mol L-1 with respect to fleroxacin. The presented method demonstrated to be a good tool for available and cost-effective point-of-need screening fluoroquinolones in milk samples.

AB - An automated and miniaturized chemiluminescence method for screening of fluoroquinolones in milk samples was proposed. The method was based on magnetic dispersive micro-solid phase extraction of analytes followed by the chemiluminescence determination of the total fluoroquinolones content using a multi-pumping flow system. In the developed method, Zr-Fe-C magnetic nanoparticles were used as an efficient sorbent for separation of fluoroquinolones from sample matrix. The chemiluminescence intensity obtained for Ce4+-SO32--Tb3+ chemiluminescence system was greatly increased in the presence of the analytes. Under the optimal conditions, the detector response for fluoroquinolones was linear in the concentration ranges from 5 center dot 10(-9) to 1 center dot 10(-6) mol L-1 with respect to fleroxacin. The limit of detection, calculated from a blank test based on 3s, was 2 center dot 10(-9) mol L-1 with respect to fleroxacin. The presented method demonstrated to be a good tool for available and cost-effective point-of-need screening fluoroquinolones in milk samples.

KW - Ammonium cerium (IV) nitrate (PubChem CID: 9869224)

KW - Ammonium hydroxide (PubChem CID: 14923)

KW - Chemiluminescence

KW - Direct-injection detector

KW - Fleroxacin (PubChem CID: 3357)

KW - Fluoroquinolones

KW - Lomefloxacin (PubChem CID: 3948)

KW - Magnetic dispersive micro-solid phase extraction

KW - Methanol (PubChem CID: 887)

KW - Milk

KW - Multi-pumping flow system

KW - Norfloxacin (PubChem CID: 4539)

KW - Ofloxacin (PubChem CID: 4583)

KW - Screening

KW - Sodium hydroxide (PubChem CID: 14798)

KW - Sodium sulfite (PubChem CID: 24437)

KW - Terbium chloride hexahydrate (PubChem CID: 203091)

KW - HPLC-FLD DETERMINATION

KW - SULFONAMIDE

KW - OFLOXACIN

KW - SENSITIZED CHEMILUMINESCENCE

KW - SOLID-PHASE EXTRACTION

KW - ASSAY

KW - MEAT

KW - LIQUID-CHROMATOGRAPHY

KW - RESIDUES

UR - http://www.scopus.com/inward/record.url?scp=85049787641&partnerID=8YFLogxK

U2 - 10.1016/j.foodchem.2018.07.073

DO - 10.1016/j.foodchem.2018.07.073

M3 - Article

VL - 270

SP - 10

EP - 16

JO - Food Chemistry

T2 - Food Chemistry

JF - Food Chemistry

SN - 0308-8146

ER -