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    Олег Викторович Шупляков
2019

Intrinsically disordered regions of synapsin hold together synaptic vesicles of the reserve pool in a living synapse

Shupliakov, O., Pechstein, A., Fredrich, K., Tomilin, N., Vorontsova, O., Sopova, E., Evergren, E., Haucke, V. & Brodin, L., 2019, In : European Neuropsychopharmacology. 29, S6, p. S287-288 P.406.

Research output

Synapsins
Synaptic Vesicles
Synapses
Axons
Lampreys

Molecular organization of the reserve pool of synaptic vesicles

Шупляков, О. В., 2019, Molecular organization of the reserve pool of synaptic vesicles.

Research output

Open Access

Vesicle clustering in a living synapse depends on a synapsin region that mediates phase separation: Synaptic vesicle clustering in a liquid phase

Pechstein, A., Tomilin, N., Walther, K., Vorontsova, O., Сопова, Е. С., Evergren, E., Haucke, V., Brodin, L. & Шупляков, О. В., 2019, (Accepted/In press) In : Cell Reports.

Research output

Vesicle shrinking and enlargement: the yin and yang of exocytotic content release: Yin and yang of fusion modes in control of release

Shin, W., Arpino, G., Thiyagarajan, S., Su, R., Ge, L., McDargh, Z., Guo, X., Wei, L., Шупляков, О. В., Jin, A., O'Shaughnessy, B. & Wu, L. G., 2019, (Accepted/In press) In : Cell Reports.

Research output

Yin-Yang
Fusion reactions
Hormones
Neuroendocrine Cells
Osmotic Pressure
4 Downloads (Pure)

Vesicle Structural Changes Control Content Release of Transmitters and Hormones

Arpino, G., Shin, W., Shupliakov, O. & Wu, L. G., 5 Aug 2019, In : Microscopy and Microanalysis. 25, S2, p. 1172-1173

Research output

Open Access
File

Исследование роли митофюзина 2 в развитии ранней патологии в дофаминергичеких нейронах

Сопова, Е. С., Онохин, К., Li, S., Сопов, А. А., Floridana, R., Коренькова, О. М., Larsson, N. G. & Шупляков, О. В., 26 Jul 2019, Актуальные проблемы трансляционной биомедицины - 2019: Сборник тезисов . СПб.: Издательство Санкт-Петербургского университета

Research outputpeer-review

2018

Endocytic scaffold Intersectin 1 regulates vesicle reclustering in the reserve pool of the giant vertebrate synapse

Шупляков, О. В., Fredrich, K., Pechstein, A., Gerth, F., Vorontsova, O., Сопова, Е. С., Коренькова, О. М., Haucke, V. & Freund, C., 2018, p. 2018-S-1926-SfN. 1 p.

Research output

Open Access
synapse
vertebrates
Petromyzontiformes
scaffolding proteins
phosphoproteins
1 Citation (Scopus)
Open Access
Synucleins
Synaptic Membranes
Parkinson Disease
Dopaminergic Neurons
Pathology

Molecular Cloning of Synucleins in River Lamprey Lampetra fluviatilis

Vorontsova, O. V., Akkuratov, E. E., Korenkova, O. M. & Shupliakov, O., 1 Jul 2018, In : Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology. 12, 3, p. 278-286 9 p.

Research output

Open Access
Synucleins
Lampreys
Cloning
Molecular Cloning
Rivers

Retromer in synaptic function and pathology

Brodin, L. & Шупляков, О. В., 24 Oct 2018, In : Frontiers in Synaptic Neuroscience. 9 p., Manuscript ID: 419761.

Research output

Open Access
Pathology
Neurodegenerative Diseases
Synapses
trans-Golgi Network
Proteins

Молекулярное клонирование синуклеинов речной миноги Lampetra fluviatilis

Vorontsova, O. V., Akkuratov, E. E., Korenkova, O. M. & Shupliakov, O. V., 2018, In : Biologicheskie Membrany. 35, 4, p. 318-327 9 p.

Research output

Open Access
2017
9 Citations (Scopus)

Intersectin associates with synapsin and regulates its nanoscale localization and function

Gerth, F., Jäpel, M., Pechstein, A., Kochlamazashvili, G., Lehmann, M., Puchkov, D., Onofri, F., Benfenati, F., Nikonenko, A. G., Fredrich, K., Shupliakov, O., Maritzen, T., Freund, C. & Haucke, V., 7 Nov 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 45, p. 12057-12062 6 p.

Research output

Open Access
Synapsins
Synaptic Vesicles
Synaptic Transmission
Endocytosis
intersectin 1
2016
55 Citations (Scopus)

Actin dynamics provides membrane tension to merge fusing vesicles into the plasma membrane

Wen, P. J., Grenklo, S., Arpino, G., Tan, X., Liao, H. S., Heureaux, J., Peng, S. Y., Chiang, H. C., Hamid, E., Zhao, W. D., Shin, W., Näreoja, T., Evergren, E., Jin, Y., Karlsson, R., Ebert, S. N., Jin, A., Liu, A. P., Shupliakov, O. & Wu, L. G., 31 Aug 2016, In : Nature Communications. 7, 12604.

Research output

Open Access
Neuroendocrine Cells
Cell membranes
Endocytosis
Merging
Actins
11 Citations (Scopus)

Sphingosine 1-phosphate lyase ablation disrupts presynaptic architecture and function via an ubiquitin- proteasome mediated mechanism

Mitroi, D. N., Deutschmann, A. U., Raucamp, M., Karunakaran, I., Glebov, K., Hans, M., Walter, J., Saba, J., Gräler, M., Ehninger, D., Sopova, E., Shupliakov, O., Swandulla, D. & Van Echten-Deckert, G., 24 Nov 2016, In : Scientific Reports. 6, 37064.

Research output

Open Access
Proteasome Endopeptidase Complex
Ubiquitin
Lyases
Neurons
Sphingolipids
2015
7 Citations (Scopus)

An endocytic scaffolding protein together with Synapsin regulates synaptic vesicle clustering in the drosophila neuromuscular junction

Winther, Å. M. E., Vorontsova, O., Rees, K. A., Näreoja, T., Sopova, E., Jiao, W. & Shupliakov, O., 4 Nov 2015, In : Journal of Neuroscience. 35, 44, p. 14756-14770 15 p.

Research output

Open Access
Synapsins
Synaptic Vesicles
Neuromuscular Junction
Drosophila
Cluster Analysis
36 Citations (Scopus)

Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease

Laguna, A., Schintu, N., Nobre, A., Alvarsson, A., Volakakis, N., Jacobsen, J. K., Gómez-Galán, M., Sopova, E., Joodmardi, E., Yoshitake, T., Deng, Q., Kehr, J., Ericson, J., Svenningsson, P., Shupliakov, O. & Perlmann, T., 28 Jun 2015, In : Nature Neuroscience. 18, 6, p. 826-835 10 p.

Research output

Mesencephalon
Parkinson Disease
Dopaminergic Neurons
Transcription Factors
Dopamine
18 Citations (Scopus)

Membrane Charge Directs the Outcome of F-BAR Domain Lipid Binding and Autoregulation

Kelley, C. F., Messelaar, E. M., Eskin, T. L., Wang, S., Song, K., Vishnia, K., Becalska, A. N., Shupliakov, O., Hagan, M. F., Danino, D., Sokolova, O. S., Nicastro, D. & Rodal, A. A., 22 Dec 2015, In : Cell Reports. 13, 11, p. 2597-2609 13 p.

Research output

Open Access
Homeostasis
Membranes
Lipids
src Homology Domains
Chemical analysis
20 Citations (Scopus)

Vesicle uncoating regulated by SH3-SH3 domain-mediated complex formation between endophilin and intersectin at synapses

Pechstein, A., Gerth, F., Milosevic, I., Jäpel, M., Eichhorn-Grünig, M., Vorontsova, O., Bacetic, J., Maritzen, T., Shupliakov, O., Freund, C. & Haucke, V., 1 Feb 2015, In : EMBO Reports. 16, 2, p. 232-239 8 p.

Research output

Open Access
src Homology Domains
Synapses
Clathrin
Synaptic Vesicles
Membranes