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    Олег Викторович Шупляков
2012
15 Citations (Scopus)

Structural organization of the presynaptic density at identified synapses in the locust central nervous system

Leitinger, G., Masich, S., Neumüller, J., Pabst, M. A., Pavelka, M., Rind, F. C., Shupliakov, O., Simmons, P. J. & Kolb, D., 1 Feb 2012, In : Journal of Comparative Neurology. 520, 2, p. 384-400 17 p.

Research output

Open Access
Grasshoppers
Synapses
Central Nervous System
Insects
Electron Microscope Tomography
2010
29 Citations (Scopus)
Neuromuscular Junction
Drosophila
Electron Microscope Tomography
Synaptic Vesicles
Synapses
14 Citations (Scopus)

Recent insights into the building and cycling of synaptic vesicles

Shupliakov, O. & Brodin, L., 1 Jan 2010, In : Experimental Cell Research. 316, 8, p. 1344-1350 7 p.

Research output

Synaptic Vesicles
Exocytosis
Endocytosis
Organelles
Neurotransmitter Agents
2011
74 Citations (Scopus)

An endophilin-dynamin complex promotes budding of clathrin-coated vesicles during synaptic vesicle recycling

Sundborger, A., Soderblom, C., Vorontsova, O., Evergren, E., Hinshaw, J. E. & Shupliakov, O., 1 Jan 2011, In : Journal of Cell Science. 124, 1, p. 133-143 11 p.

Research output

Open Access
Clathrin-Coated Vesicles
Dynamins
Clathrin
Synaptic Vesicles
Neck
2018

Молекулярное клонирование синуклеинов речной миноги Lampetra fluviatilis

Vorontsova, O. V., Akkuratov, E. E., Korenkova, O. M. & Shupliakov, O. V., 2018, In : Biologicheskie Membrany. 35, 4, p. 318-327 9 p.

Research output

Open Access
2010

Presynaptic Endosomes

Shupliakov, O. & Fernández-Chacón, R., 1 Dec 2010, Encyclopedia of Neuroscience. Elsevier, p. 975-979 5 p.

Research output

Endosomes
Adaptor Protein Complex 3
rab5 GTP-Binding Proteins
SNARE Proteins
Monomeric GTP-Binding Proteins
2018
1 Citation (Scopus)
Open Access
Synucleins
Synaptic Membranes
Parkinson Disease
Dopaminergic Neurons
Pathology
2010
16 Citations (Scopus)

Targeted disruption of the Mast syndrome gene SPG21 in mice impairs hind limb function and alters axon branching in cultured cortical neurons

Soderblom, C., Stadler, J., Jupille, H., Blackstone, C., Shupliakov, O. & Hanna, M. C., 1 Oct 2010, In : Neurogenetics. 11, 4, p. 369-378 10 p.

Research output

Hereditary Spastic Paraplegia
Axons
Extremities
Neurons
Animal Models
2016
55 Citations (Scopus)

Actin dynamics provides membrane tension to merge fusing vesicles into the plasma membrane

Wen, P. J., Grenklo, S., Arpino, G., Tan, X., Liao, H. S., Heureaux, J., Peng, S. Y., Chiang, H. C., Hamid, E., Zhao, W. D., Shin, W., Näreoja, T., Evergren, E., Jin, Y., Karlsson, R., Ebert, S. N., Jin, A., Liu, A. P., Shupliakov, O. & Wu, L. G., 31 Aug 2016, In : Nature Communications. 7, 12604.

Research output

Open Access
Neuroendocrine Cells
Cell membranes
Endocytosis
Merging
Actins
2013
15 Citations (Scopus)

The dynamin-binding domains of Dap160/intersectin affect bulk membrane retrieval in synapses

Winther, Å. M. E., Jiao, W., Vorontsova, O., Rees, K. A., Koh, T. W., Sopova, E., Schulze, K. L., Bellen, H. J. & Shupliakov, O., 15 Feb 2013, In : Journal of Cell Science. 126, 4, p. 1021-1031 11 p.

Research output

Open Access
Dynamins
Synapses
Membranes
Proteins
Synaptic Vesicles
2010
46 Citations (Scopus)

Regulation of synaptic vesicle recycling by complex formation between intersectin 1 and the clathrin adaptor complex AP2

Pechstein, A., Bacetic, J., Vahedi-Faridi, A., Gromova, K., Sundborger, A., Tomlin, N., Krainer, G., Vorontsova, O., Schäfer, J. G., Owe, S. G., Cousin, M. A., Saenger, W., Shupliakov, O. & Haucke, V., 2 Mar 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 9, p. 4206-4211 6 p.

Research output

Open Access
Vesicular Transport Adaptor Proteins
Clathrin
Synaptic Vesicles
Synapses
Membranes
41 Citations (Scopus)

Intersectin 1: A versatile actor in the synaptic vesicle cycle

Pechstein, A., Shupliakov, O. & Haucke, V., 17 Feb 2010, In : Biochemical Society Transactions. 38, 1, p. 181-186 6 p.

Research output

Synaptic Vesicles
Multiprotein Complexes
Clathrin
Electric fuses
Membrane Lipids
2011
275 Citations (Scopus)

Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition

Von Kleist, L., Stahlschmidt, W., Bulut, H., Gromova, K., Puchkov, D., Robertson, M. J., MacGregor, K. A., Tomlin, N., Pechstein, A., Chau, N., Chircop, M., Sakoff, J., Von Kries, J. P., Saenger, W., Kräusslich, H. G., Shupliakov, O., Robinson, P. J., McCluskey, A. & Haucke, V., 5 Aug 2011, In : Cell. 146, 3, p. 471-484 14 p.

Research output

Open Access
Clathrin
Molecules
Endocytosis
Cell Physiological Phenomena
Pathogens
62 Citations (Scopus)

How synapsin I may cluster synaptic vesicles

Shupliakov, O., Haucke, V. & Pechstein, A., 1 Jan 2011, In : Seminars in Cell and Developmental Biology. 22, 4, p. 393-399 7 p.

Research output

Synapsins
Synaptic Vesicles
Actin Cytoskeleton
Synapses
Cluster Analysis
405 Citations (Scopus)

A pericyte origin of spinal cord scar tissue

Göritz, C., Dias, D. O., Tomilin, N., Barbacid, M., Shupliakov, O. & Frisén, J., 8 Jul 2011, In : Science. 333, 6039, p. 238-242 5 p.

Research output

Pericytes
Cicatrix
Spinal Cord
Astrocytes
Nervous System Trauma
2010
92 Citations (Scopus)

Molecular basis for SH3 domain regulation of F-BAR-mediated membrane deformation

Rao, Y., Ma, Q., Vahedi-Faridi, A., Sundborger, A., Pechstein, A., Puchkov, D., Luo, L., Shupliakov, O., Saenger, W. & Haucke, V., 4 May 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 18, p. 8213-8218 6 p.

Research output

Open Access
src Homology Domains
Membranes
Dynamins
Dynamin I
Transport Vesicles
2019
4 Downloads (Pure)

Vesicle Structural Changes Control Content Release of Transmitters and Hormones

Arpino, G., Shin, W., Shupliakov, O. & Wu, L. G., 5 Aug 2019, In : Microscopy and Microanalysis. 25, S2, p. 1172-1173

Research output

Open Access
File
2011
3 Citations (Scopus)

Erratum: Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition (Cell (2011)146 (471-484))

Von Kleist, L., Stahlschmidt, W., Bulut, H., Gromova, K., Puchkov, D., Robertson, M. J., MacGregor, K. A., Tomilin, N., Pechstein, A., Chau, N., Chircop, M., Sakoff, J., Peter Von Kries, J., Saenger, W., Kräusslich, H. G., Shupliakov, O., Robinson, P. J., McCluskey, A. & Haucke, V., 2 Sep 2011, In : Cell. 146, 5, 1 p.

Research output

Open Access
215 Citations (Scopus)

Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission

Zhao, J., Liu, T., Jin, S., Wang, X., Qu, M., Uhlén, P., Tomilin, N., Shupliakov, O., Lendahl, U. & Nistér, M., 20 Jul 2011, In : EMBO Journal. 30, 14, p. 2762-2778 17 p.

Research output

Open Access
Mitochondrial Dynamics
Dynamins
Mitochondrial Membranes
Fusion reactions
Membranes
2013
27 Citations (Scopus)

Fast neurotransmitter release regulated by the endocytic scaffold intersectin

Sakaba, T., Kononenko, N. L., Bacetic, J., Pechstein, A., Schmoranzer, J., Yao, L., Barth, H., Shupliakov, O., Kobler, O., Aktories, K. & Haucke, V., 14 May 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 20, p. 8266-8271 6 p.

Research output

Open Access
Neurotransmitter Agents
Synaptic Vesicles
Dynamins
Membranes
GTP Phosphohydrolases
2019

Intrinsically disordered regions of synapsin hold together synaptic vesicles of the reserve pool in a living synapse

Shupliakov, O., Pechstein, A., Fredrich, K., Tomilin, N., Vorontsova, O., Sopova, E., Evergren, E., Haucke, V. & Brodin, L., 2019, In : European Neuropsychopharmacology. 29, S6, p. S287-288 P.406.

Research output

Synapsins
Synaptic Vesicles
Synapses
Axons
Lampreys
2010
23 Citations (Scopus)
Open Access
Synaptic Vesicles
Presynaptic Terminals
Cluster Analysis
Synapsins
Actin Cytoskeleton
2015
19 Citations (Scopus)

Vesicle uncoating regulated by SH3-SH3 domain-mediated complex formation between endophilin and intersectin at synapses

Pechstein, A., Gerth, F., Milosevic, I., Jäpel, M., Eichhorn-Grünig, M., Vorontsova, O., Bacetic, J., Maritzen, T., Shupliakov, O., Freund, C. & Haucke, V., 1 Feb 2015, In : EMBO Reports. 16, 2, p. 232-239 8 p.

Research output

Open Access
src Homology Domains
Synapses
Clathrin
Synaptic Vesicles
Membranes
2019

Molecular organization of the reserve pool of synaptic vesicles

Шупляков, О. В., 2019, Molecular organization of the reserve pool of synaptic vesicles.

Research output

Vesicle clustering in a living synapse depends on a synapsin region that mediates phase separation: Synaptic vesicle clustering in a liquid phase

Pechstein, A., Tomilin, N., Walther, K., Vorontsova, O., Сопова, Е. С., Evergren, E., Haucke, V., Brodin, L. & Шупляков, О. В., 2019, (Accepted/In press) In : Cell Reports.

Research output

2010
7 Citations (Scopus)
Synapses
Antibodies
Neuromuscular Junction
Drosophila
Electrons
2018

Retromer in synaptic function and pathology

Brodin, L. & Шупляков, О. В., 24 Oct 2018, In : Frontiers in Synaptic Neuroscience. 9 p., Manuscript ID: 419761.

Research output

Open Access
Pathology
Neurodegenerative Diseases
Synapses
trans-Golgi Network
Proteins
2015
18 Citations (Scopus)

Membrane Charge Directs the Outcome of F-BAR Domain Lipid Binding and Autoregulation

Kelley, C. F., Messelaar, E. M., Eskin, T. L., Wang, S., Song, K., Vishnia, K., Becalska, A. N., Shupliakov, O., Hagan, M. F., Danino, D., Sokolova, O. S., Nicastro, D. & Rodal, A. A., 22 Dec 2015, In : Cell Reports. 13, 11, p. 2597-2609 13 p.

Research output

Open Access
Homeostasis
Membranes
Lipids
src Homology Domains
Chemical analysis
2016
11 Citations (Scopus)

Sphingosine 1-phosphate lyase ablation disrupts presynaptic architecture and function via an ubiquitin- proteasome mediated mechanism

Mitroi, D. N., Deutschmann, A. U., Raucamp, M., Karunakaran, I., Glebov, K., Hans, M., Walter, J., Saba, J., Gräler, M., Ehninger, D., Sopova, E., Shupliakov, O., Swandulla, D. & Van Echten-Deckert, G., 24 Nov 2016, In : Scientific Reports. 6, 37064.

Research output

Open Access
Proteasome Endopeptidase Complex
Ubiquitin
Lyases
Neurons
Sphingolipids
2018

Molecular Cloning of Synucleins in River Lamprey Lampetra fluviatilis

Vorontsova, O. V., Akkuratov, E. E., Korenkova, O. M. & Shupliakov, O., 1 Jul 2018, In : Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology. 12, 3, p. 278-286 9 p.

Research output

Open Access
Synucleins
Lampreys
Cloning
Molecular Cloning
Rivers
2015
7 Citations (Scopus)

An endocytic scaffolding protein together with Synapsin regulates synaptic vesicle clustering in the drosophila neuromuscular junction

Winther, Å. M. E., Vorontsova, O., Rees, K. A., Näreoja, T., Sopova, E., Jiao, W. & Shupliakov, O., 4 Nov 2015, In : Journal of Neuroscience. 35, 44, p. 14756-14770 15 p.

Research output

Open Access
Synapsins
Synaptic Vesicles
Neuromuscular Junction
Drosophila
Cluster Analysis
35 Citations (Scopus)

Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease

Laguna, A., Schintu, N., Nobre, A., Alvarsson, A., Volakakis, N., Jacobsen, J. K., Gómez-Galán, M., Sopova, E., Joodmardi, E., Yoshitake, T., Deng, Q., Kehr, J., Ericson, J., Svenningsson, P., Shupliakov, O. & Perlmann, T., 28 Jun 2015, In : Nature Neuroscience. 18, 6, p. 826-835 10 p.

Research output

Mesencephalon
Parkinson Disease
Dopaminergic Neurons
Transcription Factors
Dopamine
2018

Endocytic scaffold Intersectin 1 regulates vesicle reclustering in the reserve pool of the giant vertebrate synapse

Шупляков, О. В., Fredrich, K., Pechstein, A., Gerth, F., Vorontsova, O., Сопова, Е. С., Коренькова, О. М., Haucke, V. & Freund, C., 2018, p. 2018-S-1926-SfN. 1 p.

Research output

Open Access
synapse
vertebrates
Petromyzontiformes
scaffolding proteins
phosphoproteins
2011
23 Citations (Scopus)

Synapsin I senses membrane curvature by an amphipathic lipid packing sensor motif

Krabben, L., Fassio, A., Bhatia, V. K., Pechstein, A., Onofri, F., Fadda, M., Messa, M., Rao, Y., Shupliakov, O., Stamou, D., Benfenati, F. & Haucke, V., 7 Dec 2011, In : Journal of Neuroscience. 31, 49, p. 18149-18154 6 p.

Research output

Open Access
Synapsins
Synaptic Vesicles
Lipids
Membranes
Activity Cycles
2019

Vesicle shrinking and enlargement: the yin and yang of exocytotic content release: Yin and yang of fusion modes in control of release

Shin, W., Arpino, G., Thiyagarajan, S., Su, R., Ge, L., McDargh, Z., Guo, X., Wei, L., Шупляков, О. В., Jin, A., O'Shaughnessy, B. & Wu, L. G., 2019, (Accepted/In press) In : Cell Reports.

Research output

Yin-Yang
Fusion reactions
Hormones
Neuroendocrine Cells
Osmotic Pressure

Исследование роли митофюзина 2 в развитии ранней патологии в дофаминергичеких нейронах

Сопова, Е. С., Онохин, К., Li, S., Сопов, А. А., Floridana, R., Коренькова, О. М., Larsson, N. G. & Шупляков, О. В., 26 Jul 2019, Актуальные проблемы трансляционной биомедицины - 2019: Сборник тезисов . СПб.: Издательство Санкт-Петербургского университета

Research outputpeer-review

Open Access
2017
9 Citations (Scopus)

Intersectin associates with synapsin and regulates its nanoscale localization and function

Gerth, F., Jäpel, M., Pechstein, A., Kochlamazashvili, G., Lehmann, M., Puchkov, D., Onofri, F., Benfenati, F., Nikonenko, A. G., Fredrich, K., Shupliakov, O., Maritzen, T., Freund, C. & Haucke, V., 7 Nov 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 45, p. 12057-12062 6 p.

Research output

Open Access
Synapsins
Synaptic Vesicles
Synaptic Transmission
Endocytosis
intersectin 1