In the present study, a new synthetic strategy towards N-acylated glycinamides was developed by the use of 1,3,5-triazinanes as formaldimine surrogates in the Ugi reaction. The targeted products were obtained in a combinatorial, diversity-oriented fashion in good yields. Further modifications allowed us to adapt this procedure for the one-pot two-step syntheses of a local anesthetic druglidocaine and several unsymmetrically substituted diketopiperazines.

Original languageEnglish
Pages (from-to)4517-4520
Number of pages4
JournalEuropean Journal of Organic Chemistry
Issue number29
Publication statusPublished - 9 Aug 2020

Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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