Bronchial asthma is a severe, common and disabling multifactorial disease. It has been shown that about 50-60% of differences in sensitivity to asthma therapy in patients are determined by genetics. The aim of the investigation was to study the role of polymorphic variants of the glucocorticoid receptor gene ( NR3C1 ) and the corticotropin releasing hormone receptorgene ( CRHR1 ) in the development and course of asthma. DNA samples of 212 asthma patients and DNA samples of 252 control individuals aged 18-67 years, living in the Republic of Bashkortostan, were used as the study material. Genotyping was performed using PCR-RFLP analysis and real-time PCR methods. The associations of the rs1876828* CT genotype of the CRHR1 gene with asthma in general group of patients and the rs242941* AC genotype of the CRHR1 gene with asthma in men were established. The association of the rs1876828* T allele of the CRHR1 gene with an early age of manifestation of bronchial obstruction was defined. The associations of the rs41423247* CG genotype of the NR3C1 gene and the rs1876828* T allele of the CRHR1 gene with significant reductions in spirometric measures in women were revealed.