Стереотаксическая лучевая терапия при локализованном раке предстательной желез

Standard

Стереотаксическая лучевая терапия при локализованном раке предстательной желез. / Vorobyov, N. A.; Martynova, N. I.; Mikhailov, A. V.; Gutsalo, Yu V.; Kubasov, A. V.

In: ОНКОУРОЛОГИЯ, Vol. 14, No. 2, 2018, p. 122-129.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{7aa7462b6ad849e683d48480ff197971,

title = "Стереотаксическая лучевая терапия при локализованном раке предстательной желез",

abstract = "Background. In the last decade, we observed a significant increase in the number of patients undergoing radiotherapy for prostate cancer (PC). It became possible with the development of new equipment that can significantly increase radiation efficiency and reduce the frequency and severity of side effects. Active investigation of new fractionation regimens led to the development of stereotactic radiotherapy (StR) technique. In this article, we describe our own experience of using StR in patients with localized PC. Material and methods. The study included 48 patients treated with CyberKnife robotic radiosurgery system. The patients received a total dose of 36.25 Gy delivered in 5 fractions. Results. At a median follow-up of 24 months, the estimated four-year prostate-specific antigen (PSA) relapse-free survival rate was 95.8 %. The median PSA nadir was 0.48 ng/mL. We observed no grade III-IV side effects (either early or late). Conclusion. Our results suggest that the use of StR allows achieving good biochemical control comparable to that achieved by other methods and demonstrates comparable and sometimes even lower toxicity.",

keywords = "CyberKnife, Hypofractionation, Prostate cancer, Radiosurgery, Stereotactic radiotherapy",

author = "Vorobyov, {N. A.} and Martynova, {N. I.} and Mikhailov, {A. V.} and Gutsalo, {Yu V.} and Kubasov, {A. V.}",

year = "2018",

doi = "10.17650/1726-9776-2018-14-2-122-129",

language = "русский",

volume = "14",

pages = "122--129",

journal = "Onkourologiya",

issn = "1726-9776",

publisher = "Издательский дом {"}АБВ-пресс{"} ",

number = "2",

}

RIS

TY - JOUR

T1 - Стереотаксическая лучевая терапия при локализованном раке предстательной желез

AU - Vorobyov, N. A.

AU - Martynova, N. I.

AU - Mikhailov, A. V.

AU - Gutsalo, Yu V.

AU - Kubasov, A. V.

PY - 2018

Y1 - 2018

N2 - Background. In the last decade, we observed a significant increase in the number of patients undergoing radiotherapy for prostate cancer (PC). It became possible with the development of new equipment that can significantly increase radiation efficiency and reduce the frequency and severity of side effects. Active investigation of new fractionation regimens led to the development of stereotactic radiotherapy (StR) technique. In this article, we describe our own experience of using StR in patients with localized PC. Material and methods. The study included 48 patients treated with CyberKnife robotic radiosurgery system. The patients received a total dose of 36.25 Gy delivered in 5 fractions. Results. At a median follow-up of 24 months, the estimated four-year prostate-specific antigen (PSA) relapse-free survival rate was 95.8 %. The median PSA nadir was 0.48 ng/mL. We observed no grade III-IV side effects (either early or late). Conclusion. Our results suggest that the use of StR allows achieving good biochemical control comparable to that achieved by other methods and demonstrates comparable and sometimes even lower toxicity.

AB - Background. In the last decade, we observed a significant increase in the number of patients undergoing radiotherapy for prostate cancer (PC). It became possible with the development of new equipment that can significantly increase radiation efficiency and reduce the frequency and severity of side effects. Active investigation of new fractionation regimens led to the development of stereotactic radiotherapy (StR) technique. In this article, we describe our own experience of using StR in patients with localized PC. Material and methods. The study included 48 patients treated with CyberKnife robotic radiosurgery system. The patients received a total dose of 36.25 Gy delivered in 5 fractions. Results. At a median follow-up of 24 months, the estimated four-year prostate-specific antigen (PSA) relapse-free survival rate was 95.8 %. The median PSA nadir was 0.48 ng/mL. We observed no grade III-IV side effects (either early or late). Conclusion. Our results suggest that the use of StR allows achieving good biochemical control comparable to that achieved by other methods and demonstrates comparable and sometimes even lower toxicity.

KW - CyberKnife

KW - Hypofractionation

KW - Prostate cancer

KW - Radiosurgery

KW - Stereotactic radiotherapy

UR - http://www.scopus.com/inward/record.url?scp=85049992049&partnerID=8YFLogxK

U2 - 10.17650/1726-9776-2018-14-2-122-129

DO - 10.17650/1726-9776-2018-14-2-122-129

M3 - статья

AN - SCOPUS:85049992049

VL - 14

SP - 122

EP - 129

JO - Onkourologiya

JF - Onkourologiya

SN - 1726-9776

IS - 2

ER -

ID: 39057549