Экспрессия хемокинового рецептора CXCR4 в опухолевой ткани как дополнительный фактор прогноза больных раком ободочной кишки.

Р.В. Орлова, А.К. Иванова, Г.А. Раскин, С.И. Кутукова, Н.В. Жукова, Н.П. Беляк, Е.Ю. Зорина

Research output: Contribution to journalArticle

Abstract

Background. The incidence of colon cancer (CC) is increasing annually. Despite radical treatment methods, patients with favorable prognostic factors (early stage, high tumor differentiation) may have distant metastases after 12 months, and, on the contrary, patients with unfavorable prognostic factors (elevated cancer embryonic antigen level after surgical treatment, deep invasion -T4) may be in remission for a long time. Most likely, this is attributable to the processes of metastasis of tumor cells, which are currently not well studied. In particular, the participation of cytokines (chemokines) and their receptors in the process of metastasis is of scientific interest. Objective. Evaluation of the effect of CXCR4 chemokine receptor expression in tumor tissue on the relapse-free survival rate in patients with stage II (рT4N0M0) and stage III (pT4N1-2M0) colon cancer. Methods. The study included 113 patients: 53 with stage II CC (group A) and 60 with stage III CC (group B). Median patient follow-up period was
Original languageRussian
Pages (from-to)44-49
JournalФАРМАТЕКА
Volume26
Issue number12
StatePublished - 2019
Externally publishedYes

Keywords

  • adjuvant chemotherapy
  • chemokine receptors
  • colon cancer
  • Cxcr4
  • адъювантная химиотерапия
  • рак ободочной кишки
  • хемокиновые рецепторы

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