Экспрессия остеопротегерина и растворимого лиганда рецептора активатора фактора транскрипции каппа-B при кальцификации аортального клапана.

И.В. Воронкина, О.Б. Иртюга, Л.В. Смагина, П.Е. Адамова, Е.В. Жидулева, А.Б. Малашичева, Ю.С. Сибагатуллина, L.P. Kruk, М.Л. Гордеев, О.М. Моисеева

Research output: Contribution to journalArticle

Abstract

The mechanism of valve calcification that is the main cause of aortic stenosis formation and progression is not yet clear. In recent years, the role of the OPG/RANKL/RANK system is considered as one of possible variants of pathogenesis of valve calcification. In presented work the differences in OPG and sRANKL levels involved in the calcification processes in tissues of patients with severe aortic stenosis have been examined. The study was performed using three groups of patients: group 1 – patients with aortic stenosis, group 2 – patients with aortic aneurysm, and group 3 – patients with aortic stenosis and aortic dilatation. In patients with aortic stenosis, the level of RANKL was significantly higher, and the level of RANKL was higher in valve than in tissue. The negative correlation between aortic dilatation and RANKL level indicated the lack of RANKL influence on pathogenesis of aortic dilatation. The obtained data confirm the increased expression of RANKL in patients with aortic valve calcification. The
Original languageRussian
Pages (from-to)57-62
JournalБИОМЕДИЦИНСКАЯ ХИМИЯ
Volume65
Issue number1
StatePublished - 2019
Externally publishedYes

Keywords

  • aortic stenosis
  • aortic valve calcification
  • OPG/RANKL/RANK system
  • аортальный стеноз
  • кальцификация аортального клапана
  • система ОПГ/RANKL/RANK

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