ЭКСПЕРИМЕНТАЛЬНОЕ ОБОСНОВАНИЕ ЭНДОТЕЛИОПРОТЕКТИВНОГО ЭФФЕКТА ИММУНОГЛОБУЛИНОВ ДЛЯ ВНУТРИВЕННОГО ВВЕДЕНИЯ ПРИ АКУШЕРСКОЙ ПАТОЛОГИИ

Sergey Vladimirovich Chepanov, Dmitry Igorevich Sokolov, Tatiana Nikolaevna Shlachtenko, Roman Viktorovich Kapustin, Larisa Sergeevna Okorokova, Ksenia Lvovna Belyakova, Sergey Alekseevich Selkov

Research output

Abstract

Objective. To evaluate the cytoprotective effect of intravenous immunoglobulins (IVIGs) against endothelial cells. Subjects and methods. The cytotoxic effects of the sera obtained from 45 pregnant women against the endothelial cells treated with IVIGs were investigated using culture, an enzyme immunoassay, and flow cytometry. Results. After treatment of endothelial cells with IVIGs, there was a reduction in the cytotoxic effect of the sera obtained from the women with recurrent miscarriage against endothelial cells. Conclusion. IVIGs are effective cytoprotectors that are able to prevent abnormalities associated with endothelial damage and dysfunction.

Original languageRussian
Pages (from-to)82-88
Number of pages7
JournalAkusherstvo i Ginekologiya (Russian Federation)
Issue number5
DOIs
Publication statusPublished - 2016
Externally publishedYes

Scopus subject areas

  • Obstetrics and Gynecology

Cite this

@article{f4d418040ddc45c1a675a89115b5bb7d,
title = "ЭКСПЕРИМЕНТАЛЬНОЕ ОБОСНОВАНИЕ ЭНДОТЕЛИОПРОТЕКТИВНОГО ЭФФЕКТА ИММУНОГЛОБУЛИНОВ ДЛЯ ВНУТРИВЕННОГО ВВЕДЕНИЯ ПРИ АКУШЕРСКОЙ ПАТОЛОГИИ",
abstract = "Objective. To evaluate the cytoprotective effect of intravenous immunoglobulins (IVIGs) against endothelial cells. Subjects and methods. The cytotoxic effects of the sera obtained from 45 pregnant women against the endothelial cells treated with IVIGs were investigated using culture, an enzyme immunoassay, and flow cytometry. Results. After treatment of endothelial cells with IVIGs, there was a reduction in the cytotoxic effect of the sera obtained from the women with recurrent miscarriage against endothelial cells. Conclusion. IVIGs are effective cytoprotectors that are able to prevent abnormalities associated with endothelial damage and dysfunction.",
keywords = "Antiphospholipid syndrome, Endothelial cells, Intravenous immunoglobulins, Miscarriage",
author = "Chepanov, {Sergey Vladimirovich} and Sokolov, {Dmitry Igorevich} and Shlachtenko, {Tatiana Nikolaevna} and Kapustin, {Roman Viktorovich} and Okorokova, {Larisa Sergeevna} and Belyakova, {Ksenia Lvovna} and Selkov, {Sergey Alekseevich}",
year = "2016",
doi = "10.18565/aig.2016.5.82-88",
language = "русский",
pages = "82--88",
journal = "АКУШЕРСТВО И ГИНЕКОЛОГИЯ",
issn = "0300-9092",
publisher = "Бионика Медиа",
number = "5",

}

ЭКСПЕРИМЕНТАЛЬНОЕ ОБОСНОВАНИЕ ЭНДОТЕЛИОПРОТЕКТИВНОГО ЭФФЕКТА ИММУНОГЛОБУЛИНОВ ДЛЯ ВНУТРИВЕННОГО ВВЕДЕНИЯ ПРИ АКУШЕРСКОЙ ПАТОЛОГИИ. / Chepanov, Sergey Vladimirovich; Sokolov, Dmitry Igorevich; Shlachtenko, Tatiana Nikolaevna; Kapustin, Roman Viktorovich; Okorokova, Larisa Sergeevna; Belyakova, Ksenia Lvovna; Selkov, Sergey Alekseevich.

In: Akusherstvo i Ginekologiya (Russian Federation), No. 5, 2016, p. 82-88.

Research output

TY - JOUR

T1 - ЭКСПЕРИМЕНТАЛЬНОЕ ОБОСНОВАНИЕ ЭНДОТЕЛИОПРОТЕКТИВНОГО ЭФФЕКТА ИММУНОГЛОБУЛИНОВ ДЛЯ ВНУТРИВЕННОГО ВВЕДЕНИЯ ПРИ АКУШЕРСКОЙ ПАТОЛОГИИ

AU - Chepanov, Sergey Vladimirovich

AU - Sokolov, Dmitry Igorevich

AU - Shlachtenko, Tatiana Nikolaevna

AU - Kapustin, Roman Viktorovich

AU - Okorokova, Larisa Sergeevna

AU - Belyakova, Ksenia Lvovna

AU - Selkov, Sergey Alekseevich

PY - 2016

Y1 - 2016

N2 - Objective. To evaluate the cytoprotective effect of intravenous immunoglobulins (IVIGs) against endothelial cells. Subjects and methods. The cytotoxic effects of the sera obtained from 45 pregnant women against the endothelial cells treated with IVIGs were investigated using culture, an enzyme immunoassay, and flow cytometry. Results. After treatment of endothelial cells with IVIGs, there was a reduction in the cytotoxic effect of the sera obtained from the women with recurrent miscarriage against endothelial cells. Conclusion. IVIGs are effective cytoprotectors that are able to prevent abnormalities associated with endothelial damage and dysfunction.

AB - Objective. To evaluate the cytoprotective effect of intravenous immunoglobulins (IVIGs) against endothelial cells. Subjects and methods. The cytotoxic effects of the sera obtained from 45 pregnant women against the endothelial cells treated with IVIGs were investigated using culture, an enzyme immunoassay, and flow cytometry. Results. After treatment of endothelial cells with IVIGs, there was a reduction in the cytotoxic effect of the sera obtained from the women with recurrent miscarriage against endothelial cells. Conclusion. IVIGs are effective cytoprotectors that are able to prevent abnormalities associated with endothelial damage and dysfunction.

KW - Antiphospholipid syndrome

KW - Endothelial cells

KW - Intravenous immunoglobulins

KW - Miscarriage

UR - http://www.scopus.com/inward/record.url?scp=84995436769&partnerID=8YFLogxK

U2 - 10.18565/aig.2016.5.82-88

DO - 10.18565/aig.2016.5.82-88

M3 - статья

AN - SCOPUS:84995436769

SP - 82

EP - 88

JO - АКУШЕРСТВО И ГИНЕКОЛОГИЯ

JF - АКУШЕРСТВО И ГИНЕКОЛОГИЯ

SN - 0300-9092

IS - 5

ER -