Since its ﬁrst detection, coronavirus disease (COVID-19) caused by coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection has spread rapidly around the world and become a pandemic. Although, SARS-CoV-2 primarily attacks the respiratory system, complications in other organ systems (cardiovascular, neurological, liver and kidney) increase the mortality risk. Currently, clinical experience indicates a wide range of COVID-19 clinical manifestations from asymptomatic to severe forms with low survival rates, associated with an aggressive inﬂammatory response. Overactivation of the immune system during COVID-19 leads to a sharp increase of levels of circulating proinﬂammatory cytokines - a cytokine storm, characterized by systemic inﬂammation, hyperferritinemia, acute respiratory distress syndrome and systemic inﬂammatory response syndrome, hemodynamic impairment, thrombosis and disseminated intravascular coagulation, damage to the lungs and other organs, multiple organ dysfunction and unvaforableprognosis.
|Translated title of the contribution||CYTOKINE STORM IN COVID-19 (REVIEW)|
|Journal||Профилактическая и клиническая медицина|
|State||Published - 2021|
- cytokine storm
- multiorgan damage