Цитокиновый шторм при COVID-19

Translated title of the contribution: CYTOKINE STORM IN COVID-19 (REVIEW)

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Since its first detection, coronavirus disease (COVID-19) caused by coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection has spread rapidly around the world and become a pandemic. Although, SARS-CoV-2 primarily attacks the respiratory system, complications in other organ systems (cardiovascular, neurological, liver and kidney) increase the mortality risk. Currently, clinical experience indicates a wide range of COVID-19 clinical manifestations from asymptomatic to severe forms with low survival rates, associated with an aggressive inflammatory response. Overactivation of the immune system during COVID-19 leads to a sharp increase of levels of circulating proinflammatory cytokines - a cytokine storm, characterized by systemic inflammation, hyperferritinemia, acute respiratory distress syndrome and systemic inflammatory response syndrome, hemodynamic impairment, thrombosis and disseminated intravascular coagulation, damage to the lungs and other organs, multiple organ dysfunction and unvaforableprognosis.
Translated title of the contributionCYTOKINE STORM IN COVID-19 (REVIEW)
Original languageRussian
Pages (from-to)89-95
JournalПрофилактическая и клиническая медицина
Issue number1(780
StatePublished - 2021

Keywords

  • coronavirus
  • immunity
  • cytokine storm
  • Hyperinflammation
  • hypercoagulation
  • multiorgan damage

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