Центральные эффекты мультипаттерной ботулинотерапии при посткоматозных длительных бессознательных состояниях.

Ю.И. Вайншенкер, В.А. Цинзерлинг, Л.А. Мелючева, В.В. Боброва, А.Д. Коротков, Н.В. Цыган, М.М. Одинак, И.В. Литвиненко

Research output: Contribution to journalArticle

Abstract

The data of electroencephalography, evoked potentials of the brain and positron emission tomography are analyzed before and 3 weeks after the multipattern botulinum toxin therapy of spasticity in 25 patients with post-comatose long-term consciousness disorders, including one patient who died against the backdrop gradual improvement of consciousness from acute heart failure four months after the end of second course of multipattern botulinum toxin therapy. Found that improvements of the brain functional state against the backdrop of reduced spasticity were observed regardless of primary brain damage origin, level of consciousness and of multipattern botulinum toxin therapy course repeatability. The observed dynamics of neurophysiological indicators had a normalizing direction, some differences associated with the initial level of consciousness. Electrophysiological changes during the improvement of consciousness against the background of multipattern botulinum toxin therapy were not specific. Features of impro
Original languageRussian
Pages (from-to)78-87
JournalВЕСТНИК РОССИЙСКОЙ ВОЕННО-МЕДИЦИНСКОЙ АКАДЕМИИ
Issue number2 (66)
StatePublished - 2019
Externally publishedYes

Keywords

  • axonal growth
  • botulinum toxin therapy
  • Disorders of consciousness
  • minimal consciousness state
  • neurogenesis
  • restoration of consciousness
  • spasticity
  • vegetative state
  • Xeomin
  • аксональный рост
  • ботулинотерапия
  • вегетативное состояние
  • восстановление сознания
  • Ксеомин
  • нейрогенез
  • посткоматозные длительные бессознательные состояния
  • состояние малого сознания
  • спастичность

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