Тропонины, молекулы адгезии и интерлейкины как диагностические маркеры сердечно-сосудистых заболеваний: экспрессия в периферических тканях.

Е.А. Карпасова, А.С. Дятлова, Н.С. Линькова, В.А. Бунин, В.О. Полякова, Ю.С. Крылова

Research output: Contribution to journalArticle

Abstract

Cardiovascular pathology (CVP) is one of the main reason of mortality of middle-aged and elderly people in developed countries. Densely the early diagnostic of CVP in middle-aged and elderly people is difficult on the reason of typically clinical finding. The early diagnostic of atherosclerosis, coronary heart disease (CHD), myocardial infarction (IM) and its correction improves survival prognosis and quality of life of patients. For validation of treatment success of atherosclerosis, CHD, IM is applied the investigation of concentration of hs-cTnT, hs-cTnI cardinal troponins, ICAM-1, V-CAM1, E-LAM1 adhesion molecules and IL-1α, -1β, -4, -5, -6, -13, -17 cytokines in blood plasma. For predictive diagnostic of these diseases it was recommended the measure of concentration of ICAM-1, GDF15 grow factor and NOTCH1 transmembrane protein in blood plasma and urine. Validation of these signal molecules expression in peripherical tissues for prognosis and treatment success characterization of cardiovascular diseases i
Original languageRussian
Pages (from-to)30-42
JournalУСПЕХИ СОВРЕМЕННОЙ БИОЛОГИИ
Volume140
Issue number1
StatePublished - 2020
Externally publishedYes

Keywords

  • adhesion molecules
  • atherosclerosis
  • coronary heart disease
  • interleukins
  • myocardial infarction
  • troponins
  • атеросклероз
  • интерлейкины
  • инфаркт миокарда
  • ишемическая болезнь сердца
  • молекулы адгезии
  • тропонины

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