ТИЕНОПИРИМИДИНОВЫЕ ПРОИЗВОДНЫЕ СПЕЦИФИЧНО АКТИВИРУЮТ СТЕРОИДОГЕНЕЗ В СЕМЕННИКАХ, НО НЕ ВЛИЯЮТ НА ФУНКЦИИ ЩИТОВИДНОЙ ЖЕЛЕЗЫ.

А.А. Бахтюков, К.В. Деркач, Д.В. Дарьин, А.О. Шпаков

Research output: Contribution to journalArticle

Abstract

The luteinizing hormone (LH) and human chorionic gonadotropin (hCG) stimulate the testosterone (T) production in Leydig cells via specifical binding to the LH/hCG receptor extracellular domain. The LH/hCG receptor can also be activated by lowmolecularweight (LMW) agonists that bind to the allosteric site located inside the transmembrane receptor channel. Since the allosteric sites in the LH/hCG and thyroidstimulating hormone (TSH) receptors share a similar structure, LMW agonists of the LH/hCG receptor can affect activity of the TSH receptor and the synthesis of thyroid hormones which depend on this receptor. When designing selective activators of steroidogenesis, it is necessary to rule out this possibility. The aim of this study was to explore the effect of the seven previously synthesized thienopyrimidines (TPs), LMW agonists of the LH/hCG receptor, on the basal and hCG and TSHstimulated adenylyl cyclase (AC) activity in plasma membranes isolated from the rat testes and thyroid as well as on the basal and
Original languageRussian
Pages (from-to)28-36
JournalЖУРНАЛ ЭВОЛЮЦИОННОЙ БИОХИМИИ И ФИЗИОЛОГИИ
Volume55
Issue number1
StatePublished - 2019
Externally publishedYes

Keywords

  • luteinizing hormone receptor
  • testosterone
  • thienopyrimidine
  • thyroid hormones
  • thyroid-stimulating hormone receptor
  • рецептор лютеинизирующего гормона
  • рецептор тиреотропного гормона
  • тестостерон
  • тиенопиримидин
  • тиреоидные гормоны

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