Comparative genomic analysis of Holospora spp., intranuclear symbionts of paramecia

Sofya K. Garushyants, Alexandra Y. Beliavskaia, Dmitry B. Malko, Maria D. Logacheva, Maria S. Rautian, Mikhail S. Gelfand

Research output: Contribution to journalArticlepeer-review

8 Scopus citations
7 Downloads (Pure)

Abstract

While most endosymbiotic bacteria are transmitted only vertically, Holospora spp., an alphaproteobacterium from the Rickettsiales order, can desert its host and invade a new one. All bacteria from the genus Holospora are intranuclear symbionts of ciliates Paramecium spp. with strict species and nuclear specificity. Comparative metabolic reconstruction based on the newly sequenced genome of Holospora curviuscula, a macronuclear symbiont of Paramecium bursaria, and known genomes of other Holospora species shows that even though all Holospora spp. can persist outside the host, they cannot synthesize most of the essential small molecules, such as amino acids, and lack some central energy metabolic pathways, including glycolysis and the citric acid cycle. As the main energy source, Holospora spp. likely rely on nucleotides pirated from the host. Holospora-specific genes absent from other Rickettsiales are possibly involved in the lifestyle switch from the infectious to the reproductive form and in cell invasion.

Translated title of the contributionСравнительно-геномный анализ бактерия рода Holospora, внутриядерных симбионтов парамеций
Original languageEnglish
Article number738
Pages (from-to)738
Number of pages11
JournalFrontiers in Microbiology
Volume9
Issue numberAPR
DOIs
StatePublished - 16 Apr 2018

Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Keywords

  • Ciliates
  • Endosymbionts
  • Genome
  • Holospora
  • Nuclear symbionts
  • Paramecia
  • Rickettsiales
  • endosymbionts
  • ciliates
  • IDENTIFICATION
  • nuclear symbionts
  • genome
  • PERIPLASMIC PROTEIN
  • EVOLUTION
  • INFECTION PROCESS
  • CAUDATUM
  • DATABASE
  • ELEGANS
  • FREE-LIVING BACTERIA
  • INSECTS
  • OBTUSA
  • paramecia

Fingerprint

Dive into the research topics of 'Comparative genomic analysis of Holospora spp., intranuclear symbionts of paramecia'. Together they form a unique fingerprint.

Cite this